TFE3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TFE3	TFE3, RCCP2, RCCX1, TFEA, bHLHe33,TFEA	transcription factor binding to IGHM enhancer 3	NM_006521	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes.

Its expression is boosted in human cells cells due to Ebola and Marburg virus infection. For bat cells samples this can be only observed for Marburg infected cultures.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	230	325	229	221	407	1414	309	621	399
Read_Max	R. aegyptiacus	Transcriptome	127	87	175	131	96	153	72	157	318
Read_Max	R. aegyptiacus	Genome	115	130	132	82	82	82	48	158	277
DESeq	H. sapiens	Genome	3929.24	4042.76	3296.18	3491.49	3559.29	13479.99	3556.31	5159.21	5352.92
DESeq	R. aegyptiacus	Transcriptome	857.94	805.21	1669.62	980.77	924.16	1327.81	688.47	869.35	2022.45
DESeq	R. aegyptiacus	Genome	1179.08	1348.04	2056.38	1187.94	1334.9	1984.22	998.58	1159.29	2542.03

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3929.24	3491.49	3556.31	-0.17	-0.14	0.03
7h	4042.76	3559.29	5159.21	-0.18	0.35	0.54
23h	3296.18	13479.99	5352.92	2.03	0.7	-1.33

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3929.24	4042.76	3296.18	0.04	-0.25	-0.29
Ebov	3491.49	3559.29	13479.99	0.03	1.95	1.92
Marv	3556.31	5159.21	5352.92	0.54	0.59	0.05

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	857.94	980.77	688.47	0.19	-0.32	-0.51
7h	805.21	924.16	869.35	0.2	0.11	-0.09
23h	1669.62	1327.81	2022.45	-0.33	0.28	0.61

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	857.94	805.21	1669.62	-0.09	0.96	1.05
Ebov	980.77	924.16	1327.81	-0.09	0.44	0.52
Marv	688.47	869.35	2022.45	0.34	1.55	1.22

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material