PACS1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PACS1 KIAA1175, NM_018026, NP_060496,FLJ10209, KIAA1175 phosphofurin acidic cluster sorting protein 1 NM_018026 pdf

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Description

The gene PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

For this gene only weak changes concerning the differential expression could be observed. For the 23 h probe of Ebola infected cells an upregulation took place, whereas the ones infected with the Marburg virus were slightly downregulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome181 229 124 225 225 619 302 349 139
Read_Max
batR. aegyptiacusTranscriptome 179 186 127 158 120 160 132 171 267
Read_Max
bat_genomeR. aegyptiacusGenome 192 154 100 156 90 96 107 188 260
DESeq
humanH. sapiensGenome 4349.36 4317.1 2952.67 4473.62 3644.65 12078.53 4856.33 4675.6 3575.11
DESeq
batR. aegyptiacusTranscriptome 1848.47 1990.66 1900.49 1770.07 1748.76 2341.52 1687.41 1760.82 2289.24
DESeq
bat_genomeR. aegyptiacusGenome 2222.38 2065.41 2278.42 2376.87 2017.97 2732.22 1999.42 1942.72 2545.46

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4349.36 4473.62 4856.33 0.04 0.16 0.12
7h 4317.1 3644.65 4675.6 -0.24 0.12 0.36
23h 2952.67 12078.53 3575.11 2.03 0.28 -1.76

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4349.36 4317.1 2952.67 -0.01 -0.56 -0.55
Ebov 4473.62 3644.65 12078.53 -0.3 1.43 1.73
Marv 4856.33 4675.6 3575.11 -0.05 -0.44 -0.39

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1848.47 1770.07 1687.41 -0.06 -0.13 -0.07
7h 1990.66 1748.76 1760.82 -0.19 -0.18 0.01
23h 1900.49 2341.52 2289.24 0.3 0.27 -0.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1848.47 1990.66 1900.49 0.11 0.04 -0.07
Ebov 1770.07 1748.76 2341.52 -0.02 0.4 0.42
Marv 1687.41 1760.82 2289.24 0.06 0.44 0.38