PACS1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PACS1	KIAA1175, NM_018026, NP_060496,FLJ10209, KIAA1175	phosphofurin acidic cluster sorting protein 1	NM_018026	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The gene PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

For this gene only weak changes concerning the differential expression could be observed. For the 23 h probe of Ebola infected cells an upregulation took place, whereas the ones infected with the Marburg virus were slightly downregulated.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	181	229	124	225	225	619	302	349	139
Read_Max	R. aegyptiacus	Transcriptome	179	186	127	158	120	160	132	171	267
Read_Max	R. aegyptiacus	Genome	192	154	100	156	90	96	107	188	260
DESeq	H. sapiens	Genome	4349.36	4317.1	2952.67	4473.62	3644.65	12078.53	4856.33	4675.6	3575.11
DESeq	R. aegyptiacus	Transcriptome	1848.47	1990.66	1900.49	1770.07	1748.76	2341.52	1687.41	1760.82	2289.24
DESeq	R. aegyptiacus	Genome	2222.38	2065.41	2278.42	2376.87	2017.97	2732.22	1999.42	1942.72	2545.46

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4349.36	4473.62	4856.33	0.04	0.16	0.12
7h	4317.1	3644.65	4675.6	-0.24	0.12	0.36
23h	2952.67	12078.53	3575.11	2.03	0.28	-1.76

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4349.36	4317.1	2952.67	-0.01	-0.56	-0.55
Ebov	4473.62	3644.65	12078.53	-0.3	1.43	1.73
Marv	4856.33	4675.6	3575.11	-0.05	-0.44	-0.39

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1848.47	1770.07	1687.41	-0.06	-0.13	-0.07
7h	1990.66	1748.76	1760.82	-0.19	-0.18	0.01
23h	1900.49	2341.52	2289.24	0.3	0.27	-0.03

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1848.47	1990.66	1900.49	0.11	0.04	-0.07
Ebov	1770.07	1748.76	2341.52	-0.02	0.4	0.42
Marv	1687.41	1760.82	2289.24	0.06	0.44	0.38

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material