NRCAM

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NRCAM	AY528240,KIAA0343, Bravo	neuronal cell adhesion molecule	NM_001037132	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

A very long gene with many exons, which is up- then down regulated in human cells during Ebola infection and in summary 3 fold upregulated during Marburg infection. No homolog was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	109	145	74	84	183	102	133	265	272
Read_Max	R. aegyptiacus	Transcriptome	3	12	3	2	6	4	3	8	3
Read_Max	R. aegyptiacus	Genome	7	3	0	5	2	2	4	6	2
DESeq	H. sapiens	Genome	2671.92	3248.28	2111.75	2617.73	3557.66	2377.56	2587.0	4646.03	8648.67
DESeq	R. aegyptiacus	Transcriptome	15.28	27.32	13.22	13.82	21.81	13.83	21.02	24.96	8.0
DESeq	R. aegyptiacus	Genome	18.91	12.78	0.0	11.85	11.16	10.44	21.37	9.52	6.85

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2671.92	2617.73	2587.0	-0.03	-0.05	-0.02
7h	3248.28	3557.66	4646.03	0.13	0.52	0.39
23h	2111.75	2377.56	8648.67	0.17	2.03	1.86

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2671.92	3248.28	2111.75	0.28	-0.34	-0.62
Ebov	2617.73	3557.66	2377.56	0.44	-0.14	-0.58
Marv	2587.0	4646.03	8648.67	0.84	1.74	0.9

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	15.28	13.82	21.02	-0.14	0.46	0.61
7h	27.32	21.81	24.96	-0.32	-0.13	0.19
23h	13.22	13.83	8.0	0.07	-0.72	-0.79

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	15.28	27.32	13.22	0.84	-0.21	-1.05
Ebov	13.82	21.81	13.83	0.66	0.0	-0.66
Marv	21.02	24.96	8.0	0.25	-1.39	-1.64

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material