NRCAM

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NRCAM AY528240,KIAA0343, Bravo neuronal cell adhesion molecule NM_001037132 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

A very long gene with many exons, which is up- then down regulated in human cells during Ebola infection and in summary 3 fold upregulated during Marburg infection. No homolog was found in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome109 145 74 84 183 102 133 265 272
Read_Max
batR. aegyptiacusTranscriptome 3 12 3 2 6 4 3 8 3
Read_Max
bat_genomeR. aegyptiacusGenome 7 3 0 5 2 2 4 6 2
DESeq
humanH. sapiensGenome 2671.92 3248.28 2111.75 2617.73 3557.66 2377.56 2587.0 4646.03 8648.67
DESeq
batR. aegyptiacusTranscriptome 15.28 27.32 13.22 13.82 21.81 13.83 21.02 24.96 8.0
DESeq
bat_genomeR. aegyptiacusGenome 18.91 12.78 0.0 11.85 11.16 10.44 21.37 9.52 6.85

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2671.92 2617.73 2587.0 -0.03 -0.05 -0.02
7h 3248.28 3557.66 4646.03 0.13 0.52 0.39
23h 2111.75 2377.56 8648.67 0.17 2.03 1.86

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2671.92 3248.28 2111.75 0.28 -0.34 -0.62
Ebov 2617.73 3557.66 2377.56 0.44 -0.14 -0.58
Marv 2587.0 4646.03 8648.67 0.84 1.74 0.9

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 15.28 13.82 21.02 -0.14 0.46 0.61
7h 27.32 21.81 24.96 -0.32 -0.13 0.19
23h 13.22 13.83 8.0 0.07 -0.72 -0.79

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 15.28 27.32 13.22 0.84 -0.21 -1.05
Ebov 13.82 21.81 13.83 0.66 0.0 -0.66
Marv 21.02 24.96 8.0 0.25 -1.39 -1.64