MCC

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MCC		mutated in colorectal cancers	NM_001085377	pdf			NONE

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Description

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. Downregulated upon MARV and EBOV infection in human. Different homologs in bat exist, that show diverging expression changes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	479	391	299	401	381	125	527	502	253
Read_Max	R. aegyptiacus	Transcriptome	174	150	111	142	97	134	128	147	132
Read_Max	R. aegyptiacus	Genome	201	156	99	150	90	80	113	184	151
DESeq	H. sapiens	Genome	13690.47	11194.11	8752.75	12889.58	10441.73	3219.75	12918.72	10024.85	8455.12
DESeq	R. aegyptiacus	Transcriptome	2145.04	2091.41	1795.44	1812.19	1825.42	1762.81	1888.75	1657.55	1781.91
DESeq	R. aegyptiacus	Genome	3676.47	3199.87	3178.85	3617.15	3202.19	3041.61	3289.26	2940.24	2973.55

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	13690.47	12889.58	12918.72	-0.09	-0.08	0.0
7h	11194.11	10441.73	10024.85	-0.1	-0.16	-0.06
23h	8752.75	3219.75	8455.12	-1.44	-0.05	1.39

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	13690.47	11194.11	8752.75	-0.29	-0.65	-0.35
Ebov	12889.58	10441.73	3219.75	-0.3	-2.0	-1.7
Marv	12918.72	10024.85	8455.12	-0.37	-0.61	-0.25

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2145.04	1812.19	1888.75	-0.24	-0.18	0.06
7h	2091.41	1825.42	1657.55	-0.2	-0.34	-0.14
23h	1795.44	1762.81	1781.91	-0.03	-0.01	0.02

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2145.04	2091.41	1795.44	-0.04	-0.26	-0.22
Ebov	1812.19	1825.42	1762.81	0.01	-0.04	-0.05
Marv	1888.75	1657.55	1781.91	-0.19	-0.08	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

MCC