MCC

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MCC mutated in colorectal cancers NM_001085377 pdf NONE

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Description

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. Downregulated upon MARV and EBOV infection in human. Different homologs in bat exist, that show diverging expression changes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome479 391 299 401 381 125 527 502 253
Read_Max
batR. aegyptiacusTranscriptome 174 150 111 142 97 134 128 147 132
Read_Max
bat_genomeR. aegyptiacusGenome 201 156 99 150 90 80 113 184 151
DESeq
humanH. sapiensGenome 13690.47 11194.11 8752.75 12889.58 10441.73 3219.75 12918.72 10024.85 8455.12
DESeq
batR. aegyptiacusTranscriptome 2145.04 2091.41 1795.44 1812.19 1825.42 1762.81 1888.75 1657.55 1781.91
DESeq
bat_genomeR. aegyptiacusGenome 3676.47 3199.87 3178.85 3617.15 3202.19 3041.61 3289.26 2940.24 2973.55

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 13690.47 12889.58 12918.72 -0.09 -0.08 0.0
7h 11194.11 10441.73 10024.85 -0.1 -0.16 -0.06
23h 8752.75 3219.75 8455.12 -1.44 -0.05 1.39

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 13690.47 11194.11 8752.75 -0.29 -0.65 -0.35
Ebov 12889.58 10441.73 3219.75 -0.3 -2.0 -1.7
Marv 12918.72 10024.85 8455.12 -0.37 -0.61 -0.25

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2145.04 1812.19 1888.75 -0.24 -0.18 0.06
7h 2091.41 1825.42 1657.55 -0.2 -0.34 -0.14
23h 1795.44 1762.81 1781.91 -0.03 -0.01 0.02

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2145.04 2091.41 1795.44 -0.04 -0.26 -0.22
Ebov 1812.19 1825.42 1762.81 0.01 -0.04 -0.05
Marv 1888.75 1657.55 1781.91 -0.19 -0.08 0.1