PGD
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PGD | PGD, 6PGD | phosphogluconate dehydrogenase | NM_002631 |  |
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NONE |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentosephosphate shunt. Deficiency of this enzyme is generally asymptomatic, andthe inheritance of this disorder is autosomal dominant. Hemolysis resultsfrom combined deficiency of 6-phosphogluconate dehydrogenase and6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
PGD is seen to be downregulated strongly in the late phase of Ebola virusinfection in human cells cells. The homolog bat cells counterpart does not show thispattern.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 1087 | 1325 | 1031 | 1177 | 1367 | 585 | 1515 | 2168 | 2149 |
Read_Max |  | R. aegyptiacus | Transcriptome | 761 | 794 | 652 | 725 | 492 | 571 | 517 | 750 | 913 |
Read_Max |  | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | H. sapiens | Genome | 8757.6 | 9137.02 | 7953.53 | 9639.77 | 7747.61 | 4465.92 | 9992.36 | 11727.47 | 17712.79 |
DESeq | | R. aegyptiacus | Transcriptome | 5749.24 | 6009.91 | 7285.02 | 5614.96 | 5544.35 | 5944.7 | 5574.15 | 5704.32 | 7769.29 |
DESeq | | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |