PGD

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PGD PGD, 6PGD phosphogluconate dehydrogenase NM_002631 pdf NONE

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Description

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentosephosphate shunt. Deficiency of this enzyme is generally asymptomatic, andthe inheritance of this disorder is autosomal dominant. Hemolysis resultsfrom combined deficiency of 6-phosphogluconate dehydrogenase and6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.

PGD is seen to be downregulated strongly in the late phase of Ebola virusinfection in human cells cells. The homolog bat cells counterpart does not show thispattern.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1087 1325 1031 1177 1367 585 1515 2168 2149
Read_Max
batR. aegyptiacusTranscriptome 761 794 652 725 492 571 517 750 913
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 8757.6 9137.02 7953.53 9639.77 7747.61 4465.92 9992.36 11727.47 17712.79
DESeq
batR. aegyptiacusTranscriptome 5749.24 6009.91 7285.02 5614.96 5544.35 5944.7 5574.15 5704.32 7769.29
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8757.6 9639.77 9992.36 0.14 0.19 0.05
7h 9137.02 7747.61 11727.47 -0.24 0.36 0.6
23h 7953.53 4465.92 17712.79 -0.83 1.16 1.99

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8757.6 9137.02 7953.53 0.06 -0.14 -0.2
Ebov 9639.77 7747.61 4465.92 -0.32 -1.11 -0.79
Marv 9992.36 11727.47 17712.79 0.23 0.83 0.59

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5749.24 5614.96 5574.15 -0.03 -0.04 -0.01
7h 6009.91 5544.35 5704.32 -0.12 -0.08 0.04
23h 7285.02 5944.7 7769.29 -0.29 0.09 0.39

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5749.24 6009.91 7285.02 0.06 0.34 0.28
Ebov 5614.96 5544.35 5944.7 -0.02 0.08 0.1
Marv 5574.15 5704.32 7769.29 0.03 0.48 0.45