ATP2B2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ATP2B2 PMCA2 ATPase, Ca++ transporting, plasma membrane 2 NM_001683 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.

The gene seems to be strong downregulated in Ebola infected human cells cells after 23 h while the homolog in bat cells shows only spurious coverage.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome269 376 360 245 438 115 302 422 204
Read_Max
batR. aegyptiacusTranscriptome 1 NA 2 NA NA NA NA NA 2
Read_Max
bat_genomeR. aegyptiacusGenome 1 0 2 1 1 1 2 3 2
DESeq
humanH. sapiensGenome 10413.73 14491.35 14546.87 10642.43 13615.49 3821.12 10467.81 13374.93 7710.29
DESeq
batR. aegyptiacusTranscriptome 1.84 1.0 3.44 1.0 1.0 1.0 1.0 1.0 2.75
DESeq
bat_genomeR. aegyptiacusGenome 0.86 0.0 7.81 1.97 2.23 1.31 7.87 1.59 3.42

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10413.73 10642.43 10467.81 0.03 0.01 -0.02
7h 14491.35 13615.49 13374.93 -0.09 -0.12 -0.03
23h 14546.87 3821.12 7710.29 -1.93 -0.92 1.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10413.73 14491.35 14546.87 0.48 0.48 0.01
Ebov 10642.43 13615.49 3821.12 0.36 -1.48 -1.83
Marv 10467.81 13374.93 7710.29 0.35 -0.44 -0.79

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.84 1.0 1.0 -0.88 -0.88 0.0
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 3.44 1.0 2.75 -1.78 -0.32 1.46

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.84 1.0 3.44 -0.88 0.9 1.78
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 1.0 2.75 0.0 1.46 1.46