GSR
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| GSR | HEL-75 | glutathione reductase |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. The gene is expressed quite highly in bat and human. It is upregulated in MARV, and downregulated in EBOV 23h in human.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 584 | 574 | 544 | 533 | 928 | 383 | 725 | 1036 | 1169 |
Read_Max |  | R. aegyptiacus | Transcriptome | 514 | 443 | 391 | 486 | 497 | 616 | 484 | 603 | 956 |
Read_Max |  | R. aegyptiacus | Genome | 588 | 563 | 337 | 485 | 458 | 377 | 443 | 748 | 1107 |
DESeq | | H. sapiens | Genome | 7636.26 | 6548.58 | 6628.1 | 6961.45 | 7529.74 | 3850.07 | 7587.94 | 8685.14 | 14688.88 |
DESeq | | R. aegyptiacus | Transcriptome | 3521.19 | 3672.61 | 3751.12 | 3841.31 | 4175.48 | 4479.3 | 4415.03 | 4175.01 | 6087.22 |
DESeq | | R. aegyptiacus | Genome | 5341.11 | 5917.85 | 5607.9 | 5715.55 | 6415.54 | 7053.13 | 6737.07 | 6295.99 | 9496.88 |