GSR

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GSR HEL-75 glutathione reductase pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. The gene is expressed quite highly in bat and human. It is upregulated in MARV, and downregulated in EBOV 23h in human.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome584 574 544 533 928 383 725 1036 1169
Read_Max
batR. aegyptiacusTranscriptome 514 443 391 486 497 616 484 603 956
Read_Max
bat_genomeR. aegyptiacusGenome 588 563 337 485 458 377 443 748 1107
DESeq
humanH. sapiensGenome 7636.26 6548.58 6628.1 6961.45 7529.74 3850.07 7587.94 8685.14 14688.88
DESeq
batR. aegyptiacusTranscriptome 3521.19 3672.61 3751.12 3841.31 4175.48 4479.3 4415.03 4175.01 6087.22
DESeq
bat_genomeR. aegyptiacusGenome 5341.11 5917.85 5607.9 5715.55 6415.54 7053.13 6737.07 6295.99 9496.88

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7636.26 6961.45 7587.94 -0.13 -0.01 0.12
7h 6548.58 7529.74 8685.14 0.2 0.41 0.21
23h 6628.1 3850.07 14688.88 -0.78 1.15 1.93

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7636.26 6548.58 6628.1 -0.22 -0.2 0.02
Ebov 6961.45 7529.74 3850.07 0.11 -0.85 -0.97
Marv 7587.94 8685.14 14688.88 0.19 0.95 0.76

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3521.19 3841.31 4415.03 0.13 0.33 0.2
7h 3672.61 4175.48 4175.01 0.19 0.18 0.0
23h 3751.12 4479.3 6087.22 0.26 0.7 0.44

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3521.19 3672.61 3751.12 0.06 0.09 0.03
Ebov 3841.31 4175.48 4479.3 0.12 0.22 0.1
Marv 4415.03 4175.01 6087.22 -0.08 0.46 0.54