IFRD1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IFRD1 B7Z5G1, IFRD1_HUMAN,PC4, TIS7 interferon-related developmental regulator 1 NM_001550 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene (interferon-related developmental regulator 1 (IFRD1)) is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants.

There were slight changes in the expression levels. Most significantly was an upregulation in the 23 h Ebola infected cells, whereas Marburg infected cells showed a slight downregulation at this timepoint.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome326 252 271 238 360 913 322 355 290
Read_Max
batR. aegyptiacusTranscriptome 161 137 102 146 112 294 137 160 149
Read_Max
bat_genomeR. aegyptiacusGenome 232 196 109 176 116 205 149 250 203
DESeq
humanH. sapiensGenome 3652.2 2932.11 3583.11 3266.78 3586.93 12146.96 3520.35 3372.66 4073.11
DESeq
batR. aegyptiacusTranscriptome 850.38 807.03 697.28 888.28 819.03 1716.61 887.59 895.78 766.37
DESeq
bat_genomeR. aegyptiacusGenome 1876.05 2022.51 1529.73 1778.46 1942.07 3370.57 2016.29 2034.7 1517.17

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3652.2 3266.78 3520.35 -0.16 -0.05 0.11
7h 2932.11 3586.93 3372.66 0.29 0.2 -0.09
23h 3583.11 12146.96 4073.11 1.76 0.18 -1.58

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3652.2 2932.11 3583.11 -0.32 -0.03 0.29
Ebov 3266.78 3586.93 12146.96 0.13 1.89 1.76
Marv 3520.35 3372.66 4073.11 -0.06 0.21 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 850.38 888.28 887.59 0.06 0.06 -0.0
7h 807.03 819.03 895.78 0.02 0.15 0.13
23h 697.28 1716.61 766.37 1.3 0.14 -1.16

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 850.38 807.03 697.28 -0.08 -0.29 -0.21
Ebov 888.28 819.03 1716.61 -0.12 0.95 1.07
Marv 887.59 895.78 766.37 0.01 -0.21 -0.23