DUSP16

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DUSP16 DUSP16, MKP-7, MKP7,MKP-7, KIAA1700 dual specificity phosphatase 16 NM_030640 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

his gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.

Its expression seems to be constantly upregulated in the course of Ebola infection in human cells and bat cells cells. Different modulation for Marburg and mock treated cells can be observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome176 168 195 176 278 736 262 269 278
Read_Max
batR. aegyptiacusTranscriptome 165 136 170 163 124 253 144 186 193
Read_Max
bat_genomeR. aegyptiacusGenome 176 160 129 130 107 133 107 217 204
DESeq
humanH. sapiensGenome 3483.75 3303.35 3066.84 3546.24 3318.65 11270.56 3537.01 3454.19 5075.65
DESeq
batR. aegyptiacusTranscriptome 1460.32 1280.84 1458.29 1323.23 1478.28 2092.59 1400.41 1288.23 1415.4
DESeq
bat_genomeR. aegyptiacusGenome 2668.41 2555.52 2656.67 2535.86 2898.6 4234.75 2906.92 2520.78 2924.75

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3483.75 3546.24 3537.01 0.03 0.02 -0.0
7h 3303.35 3318.65 3454.19 0.01 0.06 0.06
23h 3066.84 11270.56 5075.65 1.88 0.73 -1.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3483.75 3303.35 3066.84 -0.08 -0.18 -0.11
Ebov 3546.24 3318.65 11270.56 -0.1 1.67 1.76
Marv 3537.01 3454.19 5075.65 -0.03 0.52 0.56

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1460.32 1323.23 1400.41 -0.14 -0.06 0.08
7h 1280.84 1478.28 1288.23 0.21 0.01 -0.2
23h 1458.29 2092.59 1415.4 0.52 -0.04 -0.56

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1460.32 1280.84 1458.29 -0.19 -0.0 0.19
Ebov 1323.23 1478.28 2092.59 0.16 0.66 0.5
Marv 1400.41 1288.23 1415.4 -0.12 0.02 0.14