CCNE2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CCNE2	cyce2, BC020729, hCG_15054, NM_057749, NP_477097, Q8WUE3, Q8WUE3_HUMAN,CYCE2	cyclin E2	NM_057749, NM_004702	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens cyclin E2 (CCNE2) protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.

This gene is downregulated in all HG19 and RAE samples, except RAE with marburg infection and the RAE MOCK 7h sample.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	64	41	28	49	34	15	58	56	27
Read_Max	R. aegyptiacus	Transcriptome	66	70	36	78	46	27	55	69	90
Read_Max	R. aegyptiacus	Genome	183	108	71	87	87	61	84	135	147
DESeq	H. sapiens	Genome	488.1	279.43	277.01	351.19	253.01	97.06	393.99	271.98	234.78
DESeq	R. aegyptiacus	Transcriptome	222.8	227.92	176.9	263.8	260.54	138.3	233.49	283.56	246.79
DESeq	R. aegyptiacus	Genome	806.97	836.93	765.42	621.13	872.82	571.77	764.68	899.99	867.32

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	488.1	351.19	393.99	-0.47	-0.31	0.17
7h	279.43	253.01	271.98	-0.14	-0.04	0.1
23h	277.01	97.06	234.78	-1.51	-0.24	1.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	488.1	279.43	277.01	-0.8	-0.82	-0.01
Ebov	351.19	253.01	97.06	-0.47	-1.86	-1.38
Marv	393.99	271.98	234.78	-0.53	-0.75	-0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	222.8	263.8	233.49	0.24	0.07	-0.18
7h	227.92	260.54	283.56	0.19	0.32	0.12
23h	176.9	138.3	246.79	-0.36	0.48	0.84

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	222.8	227.92	176.9	0.03	-0.33	-0.37
Ebov	263.8	260.54	138.3	-0.02	-0.93	-0.91
Marv	233.49	283.56	246.79	0.28	0.08	-0.2

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material