DENND5A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DENND5A	DENND5A, RAB6IP1,KIAA1091, FLJ22354, FLJ33829, FLJ43455	DENN/MADD domain containing 5A	NM_015213	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Its expression is modulated in human cells cells at 23 h after Ebola infection. Interestingly, in bat cells this effect can be seen due to Marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	158	158	155	150	220	637	222	315	188
Read_Max	R. aegyptiacus	Transcriptome	365	364	267	438	370	327	222	444	387
Read_Max	R. aegyptiacus	Genome	418	494	281	358	322	241	275	637	648
DESeq	H. sapiens	Genome	2882.99	3152.41	2786.87	3104.8	3254.43	10173.08	3175.6	3607.67	3709.94
DESeq	R. aegyptiacus	Transcriptome	3770.71	3816.93	4080.93	4564.69	4810.64	4454.92	3817.67	4568.28	4369.3
DESeq	R. aegyptiacus	Genome	6656.84	8015.2	6742.64	7120.74	8473.69	7759.36	6877.64	7674.92	7260.51

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2882.99	3104.8	3175.6	0.11	0.14	0.03
7h	3152.41	3254.43	3607.67	0.05	0.19	0.15
23h	2786.87	10173.08	3709.94	1.87	0.41	-1.46

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2882.99	3152.41	2786.87	0.13	-0.05	-0.18
Ebov	3104.8	3254.43	10173.08	0.07	1.71	1.64
Marv	3175.6	3607.67	3709.94	0.18	0.22	0.04

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3770.71	4564.69	3817.67	0.28	0.02	-0.26
7h	3816.93	4810.64	4568.28	0.33	0.26	-0.07
23h	4080.93	4454.92	4369.3	0.13	0.1	-0.03

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3770.71	3816.93	4080.93	0.02	0.11	0.1
Ebov	4564.69	4810.64	4454.92	0.08	-0.04	-0.11
Marv	3817.67	4568.28	4369.3	0.26	0.19	-0.06

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material