DENND5A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DENND5A DENND5A, RAB6IP1,KIAA1091, FLJ22354, FLJ33829, FLJ43455 DENN/MADD domain containing 5A NM_015213 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Its expression is modulated in human cells cells at 23 h after Ebola infection. Interestingly, in bat cells this effect can be seen due to Marburg infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome158 158 155 150 220 637 222 315 188
Read_Max
batR. aegyptiacusTranscriptome 365 364 267 438 370 327 222 444 387
Read_Max
bat_genomeR. aegyptiacusGenome 418 494 281 358 322 241 275 637 648
DESeq
humanH. sapiensGenome 2882.99 3152.41 2786.87 3104.8 3254.43 10173.08 3175.6 3607.67 3709.94
DESeq
batR. aegyptiacusTranscriptome 3770.71 3816.93 4080.93 4564.69 4810.64 4454.92 3817.67 4568.28 4369.3
DESeq
bat_genomeR. aegyptiacusGenome 6656.84 8015.2 6742.64 7120.74 8473.69 7759.36 6877.64 7674.92 7260.51

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2882.99 3104.8 3175.6 0.11 0.14 0.03
7h 3152.41 3254.43 3607.67 0.05 0.19 0.15
23h 2786.87 10173.08 3709.94 1.87 0.41 -1.46

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2882.99 3152.41 2786.87 0.13 -0.05 -0.18
Ebov 3104.8 3254.43 10173.08 0.07 1.71 1.64
Marv 3175.6 3607.67 3709.94 0.18 0.22 0.04

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3770.71 4564.69 3817.67 0.28 0.02 -0.26
7h 3816.93 4810.64 4568.28 0.33 0.26 -0.07
23h 4080.93 4454.92 4369.3 0.13 0.1 -0.03

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3770.71 3816.93 4080.93 0.02 0.11 0.1
Ebov 4564.69 4810.64 4454.92 0.08 -0.04 -0.11
Marv 3817.67 4568.28 4369.3 0.26 0.19 -0.06