HMGN2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| HMGN2 | HMG17, see also Pseudogene: HMGN2P4 | high mobility group nucleosomal binding domain 2 | NM_005517 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. The HMGN2 gene is very high expressed and strongly downregulated in ebola infected cells after 23 hours, especially in human cells (7-fold), but also in bat cells (2-fold). Interestling the last exon at position 26,801,500-26,802,500 on chromosome 1 shows no splitted reads to the previous exons indicating a missing splicing of this exon.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 2276 | 1971 | 1993 | 2011 | 3453 | 782 | 2736 | 2304 | 1662 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 3096 | 2771 | 1579 | 2662 | 2123 | 879 | 2297 | 4400 | 2669 |
DESeq | | H. sapiens | Genome | 2599.87 | 2395.66 | 2339.1 | 2553.85 | 3077.21 | 849.77 | 2733.49 | 2153.65 | 2202.88 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 11059.49 | 12062.04 | 9239.76 | 12709.9 | 12632.4 | 6541.41 | 13335.83 | 12345.38 | 8484.0 |