HMGN2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HMGN2 HMG17, see also Pseudogene: HMGN2P4 high mobility group nucleosomal binding domain 2 NM_005517 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. The HMGN2 gene is very high expressed and strongly downregulated in ebola infected cells after 23 hours, especially in human cells (7-fold), but also in bat cells (2-fold). Interestling the last exon at position 26,801,500-26,802,500 on chromosome 1 shows no splitted reads to the previous exons indicating a missing splicing of this exon.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2276 1971 1993 2011 3453 782 2736 2304 1662
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 3096 2771 1579 2662 2123 879 2297 4400 2669
DESeq
humanH. sapiensGenome 2599.87 2395.66 2339.1 2553.85 3077.21 849.77 2733.49 2153.65 2202.88
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 11059.49 12062.04 9239.76 12709.9 12632.4 6541.41 13335.83 12345.38 8484.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2599.87 2553.85 2733.49 -0.03 0.07 0.1
7h 2395.66 3077.21 2153.65 0.36 -0.15 -0.51
23h 2339.1 849.77 2202.88 -1.46 -0.09 1.37

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2599.87 2395.66 2339.1 -0.12 -0.15 -0.03
Ebov 2553.85 3077.21 849.77 0.27 -1.59 -1.86
Marv 2733.49 2153.65 2202.88 -0.34 -0.31 0.03

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA