THEM4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
THEM4 B2RBX2, CTMP, NM_053055, NP_444283, Q5T1C6, Q96KR2, THEM4_HUMAN,CTMP thioesterase superfamily member 4 NM_053055 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens thioesterase superfamily member 4 (THEM4) or Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.

This gene has no homolog in RAE, but is strongly downregulated during ebola infection. HG19 and HG19 marburg shows similar behaviours, but are less downregulated.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome136 97 70 130 139 47 134 108 61
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 13 10 3 5 3 2 3 5 5
DESeq
humanH. sapiensGenome 1846.9 1190.17 930.28 1506.7 1240.75 416.83 1374.7 1259.98 861.09
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 18.91 17.34 21.2 13.82 7.81 7.83 16.87 11.89 27.4

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1846.9 1506.7 1374.7 -0.29 -0.43 -0.13
7h 1190.17 1240.75 1259.98 0.06 0.08 0.02
23h 930.28 416.83 861.09 -1.16 -0.11 1.05

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1846.9 1190.17 930.28 -0.63 -0.99 -0.36
Ebov 1506.7 1240.75 416.83 -0.28 -1.85 -1.57
Marv 1374.7 1259.98 861.09 -0.13 -0.67 -0.55

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA