FMNL2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FMNL2	FMNL2, FHOD2,KIAA1902	formin-like 2	NM_052905	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined.

Its expression is modulated in late infection phase in human cells and bat cells cells due to Ebola (but not Marburg) infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	212	345	280	243	388	440	338	418	261
Read_Max	R. aegyptiacus	Transcriptome	283	219	192	205	223	500	279	326	367
Read_Max	R. aegyptiacus	Genome	460	347	211	309	246	341	279	431	452
DESeq	H. sapiens	Genome	2852.55	3933.63	4254.26	2768.3	3942.19	9959.9	2783.49	3988.16	6734.94
DESeq	R. aegyptiacus	Transcriptome	755.45	661.8	733.92	671.27	799.32	1644.76	904.27	832.17	1020.04
DESeq	R. aegyptiacus	Genome	7564.35	7034.06	6856.45	6735.63	7572.97	14627.12	7619.83	7107.97	8434.34

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2852.55	2768.3	2783.49	-0.04	-0.04	0.01
7h	3933.63	3942.19	3988.16	0.0	0.02	0.02
23h	4254.26	9959.9	6734.94	1.23	0.66	-0.56

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2852.55	3933.63	4254.26	0.46	0.58	0.11
Ebov	2768.3	3942.19	9959.9	0.51	1.85	1.34
Marv	2783.49	3988.16	6734.94	0.52	1.27	0.76

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	755.45	671.27	904.27	-0.17	0.26	0.43
7h	661.8	799.32	832.17	0.27	0.33	0.06
23h	733.92	1644.76	1020.04	1.16	0.47	-0.69

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	755.45	661.8	733.92	-0.19	-0.04	0.15
Ebov	671.27	799.32	1644.76	0.25	1.29	1.04
Marv	904.27	832.17	1020.04	-0.12	0.17	0.29

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material