LMNB1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LMNB1 lamin B1 NM_005573 pdf NONE

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Description

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

The gene seems to be downregulated 23 h after infection with Ebola or Marburg. In bat cells the downregulation seems to be earlier 7 h after infection with Ebola.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome747 667 561 673 880 240 980 982 340
Read_Max
batR. aegyptiacusTranscriptome 896 879 415 644 572 509 694 832 606
Read_Max
bat_genomeR. aegyptiacusGenome 972 667 367 861 468 298 597 1000 659
DESeq
humanH. sapiensGenome 9986.5 8936.11 7476.97 9667.15 8320.74 2690.74 9696.74 8750.69 5404.03
DESeq
batR. aegyptiacusTranscriptome 6871.67 7566.59 4553.67 6307.21 6578.11 5504.57 7883.51 7144.4 5488.05
DESeq
bat_genomeR. aegyptiacusGenome 8162.49 7176.44 5002.03 9259.63 7712.48 6504.86 9503.42 8087.26 6142.32

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9986.5 9667.15 9696.74 -0.05 -0.04 0.0
7h 8936.11 8320.74 8750.69 -0.1 -0.03 0.07
23h 7476.97 2690.74 5404.03 -1.47 -0.47 1.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9986.5 8936.11 7476.97 -0.16 -0.42 -0.26
Ebov 9667.15 8320.74 2690.74 -0.22 -1.85 -1.63
Marv 9696.74 8750.69 5404.03 -0.15 -0.84 -0.7

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6871.67 6307.21 7883.51 -0.12 0.2 0.32
7h 7566.59 6578.11 7144.4 -0.2 -0.08 0.12
23h 4553.67 5504.57 5488.05 0.27 0.27 -0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6871.67 7566.59 4553.67 0.14 -0.59 -0.73
Ebov 6307.21 6578.11 5504.57 0.06 -0.2 -0.26
Marv 7883.51 7144.4 5488.05 -0.14 -0.52 -0.38