STAT6

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
STAT6	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C,D12S1644	signal transducer and activator of transcription 6, interleukin-4 induced	NM_003153	pdf

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Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.

This gene is expressed in human and bat in all probes. It is upregulated in Marburg infected probes already after 7h and stays on the same level afterwards. However, in Ebola infected probes the expression is strongly upregulated in the 23h probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	26	34	43	30	32	97	37	60	58
Read_Max	R. aegyptiacus	Transcriptome	62	58	62	61	49	97	39	81	94
Read_Max	R. aegyptiacus	Genome	74	64	57	51	41	54	28	117	111
DESeq	H. sapiens	Genome	584.5	581.31	774.41	582.75	552.99	1986.73	623.82	745.2	1290.59
DESeq	R. aegyptiacus	Transcriptome	660.51	698.11	936.7	768.33	745.66	1182.81	561.65	875.95	1060.27
DESeq	R. aegyptiacus	Genome	582.67	710.07	817.87	650.75	647.36	1031.27	441.94	808.01	970.92

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	584.5	582.75	623.82	-0.0	0.09	0.1
7h	581.31	552.99	745.2	-0.07	0.36	0.43
23h	774.41	1986.73	1290.59	1.36	0.74	-0.62

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	584.5	581.31	774.41	-0.01	0.41	0.41
Ebov	582.75	552.99	1986.73	-0.08	1.77	1.85
Marv	623.82	745.2	1290.59	0.26	1.05	0.79

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	660.51	768.33	561.65	0.22	-0.23	-0.45
7h	698.11	745.66	875.95	0.1	0.33	0.23
23h	936.7	1182.81	1060.27	0.34	0.18	-0.16

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	660.51	698.11	936.7	0.08	0.5	0.42
Ebov	768.33	745.66	1182.81	-0.04	0.62	0.67
Marv	561.65	875.95	1060.27	0.64	0.92	0.28

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material