TRIM6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TRIM6 A8K2A7, NM_058166, NP_001185574, Q86WZ8, Q9C030, Q9HCR1, RNF89, TRIM6_HUMAN,RNF89 tripartite motif containing 6 NM_001003818 pdf

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Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members.

This gene was slightly differential expressed. The strongest regulation was found for the EBOV-infected cell between 7 h and 23 h p.i. with a twofold downregulation.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome80 89 120 86 106 62 112 132 155
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 30 27 24 25 29 21 22 57 50
DESeq
humanH. sapiensGenome 967.08 1075.95 1517.04 1153.09 1206.61 624.75 1180.84 1074.53 2232.24
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 236.33 335.87 305.72 237.0 362.74 279.36 291.25 371.89 464.06

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 967.08 1153.09 1180.84 0.25 0.29 0.03
7h 1075.95 1206.61 1074.53 0.17 -0.0 -0.17
23h 1517.04 624.75 2232.24 -1.28 0.56 1.84

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 967.08 1075.95 1517.04 0.15 0.65 0.5
Ebov 1153.09 1206.61 624.75 0.07 -0.88 -0.95
Marv 1180.84 1074.53 2232.24 -0.14 0.92 1.05

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA