UBR4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
UBR4 RBAF600, ZUBR1, p600,KIAA1307, KIAA0462, RBAF600 ubiquitin protein ligase E3 component n-recognin 4 NM_020765 pdf

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Description

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.Moderately high expression with upregulation in EBOV infection in human, and MARV infection in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome111 112 125 94 154 426 127 124 132
Read_Max
batR. aegyptiacusTranscriptome 147 98 85 88 90 153 73 95 172
Read_Max
bat_genomeR. aegyptiacusGenome 148 85 73 91 72 93 56 110 176
DESeq
humanH. sapiensGenome 7329.79 8918.77 9649.27 8151.18 9236.12 28936.81 7382.68 7648.39 9971.97
DESeq
batR. aegyptiacusTranscriptome 5387.98 4717.36 5347.67 4997.8 5472.07 7748.85 5065.78 4155.18 5216.89
DESeq
bat_genomeR. aegyptiacusGenome 5085.87 4416.48 4843.59 4683.63 4816.12 7171.92 4699.42 3645.17 4539.53

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7329.79 8151.18 7382.68 0.15 0.01 -0.14
7h 8918.77 9236.12 7648.39 0.05 -0.22 -0.27
23h 9649.27 28936.81 9971.97 1.58 0.05 -1.54

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7329.79 8918.77 9649.27 0.28 0.4 0.11
Ebov 8151.18 9236.12 28936.81 0.18 1.83 1.65
Marv 7382.68 7648.39 9971.97 0.05 0.43 0.38

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5387.98 4997.8 5065.78 -0.11 -0.09 0.02
7h 4717.36 5472.07 4155.18 0.21 -0.18 -0.4
23h 5347.67 7748.85 5216.89 0.54 -0.04 -0.57

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5387.98 4717.36 5347.67 -0.19 -0.01 0.18
Ebov 4997.8 5472.07 7748.85 0.13 0.63 0.5
Marv 5065.78 4155.18 5216.89 -0.29 0.04 0.33