SEPHS2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SEPHS2	SPS2, SPS2b	selenophosphate synthetase 2	NM_012248	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. Gene is highly expressed in human, but downregulated in EBOV (4 fold) and MARV (2 fold) 23h data. The homolog in bat shows no significant expression change.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	714	887	834	776	1065	250	1018	1088	470
Read_Max	R. aegyptiacus	Transcriptome	420	419	297	399	367	320	365	546	446
Read_Max	R. aegyptiacus	Genome	159	137	87	158	107	83	101	207	174
DESeq	H. sapiens	Genome	8812.39	10311.92	8925.5	10068.67	9742.59	2834.18	10107.28	9295.05	6309.79
DESeq	R. aegyptiacus	Transcriptome	2817.15	2976.41	2214.42	2889.02	2965.41	2137.5	3109.06	3062.1	2462.43
DESeq	R. aegyptiacus	Genome	1245.26	1290.54	1171.57	1415.06	1356.1	1407.23	1475.39	1294.09	1315.97

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8812.39	10068.67	10107.28	0.19	0.2	0.01
7h	10311.92	9742.59	9295.05	-0.08	-0.15	-0.07
23h	8925.5	2834.18	6309.79	-1.66	-0.5	1.15

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8812.39	10311.92	8925.5	0.23	0.02	-0.21
Ebov	10068.67	9742.59	2834.18	-0.05	-1.83	-1.78
Marv	10107.28	9295.05	6309.79	-0.12	-0.68	-0.56

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2817.15	2889.02	3109.06	0.04	0.14	0.11
7h	2976.41	2965.41	3062.1	-0.01	0.04	0.05
23h	2214.42	2137.5	2462.43	-0.05	0.15	0.2

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2817.15	2976.41	2214.42	0.08	-0.35	-0.43
Ebov	2889.02	2965.41	2137.5	0.04	-0.43	-0.47
Marv	3109.06	3062.1	2462.43	-0.02	-0.34	-0.31

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material