SEPHS2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SEPHS2 SPS2, SPS2b selenophosphate synthetase 2 NM_012248 pdf NONE

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Description

This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. Gene is highly expressed in human, but downregulated in EBOV (4 fold) and MARV (2 fold) 23h data. The homolog in bat shows no significant expression change.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome714 887 834 776 1065 250 1018 1088 470
Read_Max
batR. aegyptiacusTranscriptome 420 419 297 399 367 320 365 546 446
Read_Max
bat_genomeR. aegyptiacusGenome 159 137 87 158 107 83 101 207 174
DESeq
humanH. sapiensGenome 8812.39 10311.92 8925.5 10068.67 9742.59 2834.18 10107.28 9295.05 6309.79
DESeq
batR. aegyptiacusTranscriptome 2817.15 2976.41 2214.42 2889.02 2965.41 2137.5 3109.06 3062.1 2462.43
DESeq
bat_genomeR. aegyptiacusGenome 1245.26 1290.54 1171.57 1415.06 1356.1 1407.23 1475.39 1294.09 1315.97

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8812.39 10068.67 10107.28 0.19 0.2 0.01
7h 10311.92 9742.59 9295.05 -0.08 -0.15 -0.07
23h 8925.5 2834.18 6309.79 -1.66 -0.5 1.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8812.39 10311.92 8925.5 0.23 0.02 -0.21
Ebov 10068.67 9742.59 2834.18 -0.05 -1.83 -1.78
Marv 10107.28 9295.05 6309.79 -0.12 -0.68 -0.56

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2817.15 2889.02 3109.06 0.04 0.14 0.11
7h 2976.41 2965.41 3062.1 -0.01 0.04 0.05
23h 2214.42 2137.5 2462.43 -0.05 0.15 0.2

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2817.15 2976.41 2214.42 0.08 -0.35 -0.43
Ebov 2889.02 2965.41 2137.5 0.04 -0.43 -0.47
Marv 3109.06 3062.1 2462.43 -0.02 -0.34 -0.31