TRIM2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRIM2	KIAA0517, NM_001130067, NP_001123539, O60272, Q9BSI9, Q9C040, Q9UFZ1, RNF86, TRIM2_HUMAN	tripartite motif containing 2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.

For this gene we saw differential expression within the human cells. For the infected cells first an upregulation (between 3 h and 7 h p.i.) and then a downregulation (between 7 h and 23 h p.i.) took place.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	132	174	152	144	191	175	152	215	250
Read_Max	R. aegyptiacus	Transcriptome	149	106	67	103	78	92	122	126	139
Read_Max	R. aegyptiacus	Genome	154	106	57	98	86	56	103	156	162
DESeq	H. sapiens	Genome	3063.63	3745.97	4198.66	2842.44	3939.75	1182.7	2622.97	3368.66	3715.38
DESeq	R. aegyptiacus	Transcriptome	1328.42	996.74	1111.38	988.09	1077.47	935.16	1265.81	1058.55	1272.83
DESeq	R. aegyptiacus	Genome	2932.24	2556.43	2331.98	2442.05	2751.27	2314.49	3135.2	2645.27	2990.68

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3063.63	2842.44	2622.97	-0.11	-0.22	-0.12
7h	3745.97	3939.75	3368.66	0.07	-0.15	-0.23
23h	4198.66	1182.7	3715.38	-1.83	-0.18	1.65

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3063.63	3745.97	4198.66	0.29	0.45	0.16
Ebov	2842.44	3939.75	1182.7	0.47	-1.27	-1.74
Marv	2622.97	3368.66	3715.38	0.36	0.5	0.14

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1328.42	988.09	1265.81	-0.43	-0.07	0.36
7h	996.74	1077.47	1058.55	0.11	0.09	-0.03
23h	1111.38	935.16	1272.83	-0.25	0.2	0.44

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1328.42	996.74	1111.38	-0.41	-0.26	0.16
Ebov	988.09	1077.47	935.16	0.12	-0.08	-0.2
Marv	1265.81	1058.55	1272.83	-0.26	0.01	0.27

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material