TRIM2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TRIM2 KIAA0517, NM_001130067, NP_001123539, O60272, Q9BSI9, Q9C040, Q9UFZ1, RNF86, TRIM2_HUMAN tripartite motif containing 2 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants.

For this gene we saw differential expression within the human cells. For the infected cells first an upregulation (between 3 h and 7 h p.i.) and then a downregulation (between 7 h and 23 h p.i.) took place.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome132 174 152 144 191 175 152 215 250
Read_Max
batR. aegyptiacusTranscriptome 149 106 67 103 78 92 122 126 139
Read_Max
bat_genomeR. aegyptiacusGenome 154 106 57 98 86 56 103 156 162
DESeq
humanH. sapiensGenome 3063.63 3745.97 4198.66 2842.44 3939.75 1182.7 2622.97 3368.66 3715.38
DESeq
batR. aegyptiacusTranscriptome 1328.42 996.74 1111.38 988.09 1077.47 935.16 1265.81 1058.55 1272.83
DESeq
bat_genomeR. aegyptiacusGenome 2932.24 2556.43 2331.98 2442.05 2751.27 2314.49 3135.2 2645.27 2990.68

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3063.63 2842.44 2622.97 -0.11 -0.22 -0.12
7h 3745.97 3939.75 3368.66 0.07 -0.15 -0.23
23h 4198.66 1182.7 3715.38 -1.83 -0.18 1.65

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3063.63 3745.97 4198.66 0.29 0.45 0.16
Ebov 2842.44 3939.75 1182.7 0.47 -1.27 -1.74
Marv 2622.97 3368.66 3715.38 0.36 0.5 0.14

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1328.42 988.09 1265.81 -0.43 -0.07 0.36
7h 996.74 1077.47 1058.55 0.11 0.09 -0.03
23h 1111.38 935.16 1272.83 -0.25 0.2 0.44

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1328.42 996.74 1111.38 -0.41 -0.26 0.16
Ebov 988.09 1077.47 935.16 0.12 -0.08 -0.2
Marv 1265.81 1058.55 1272.83 -0.26 0.01 0.27