MAST2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAST2	MAST205, MTSSK, KIAA0807	microtubule associated serine/threonine kinase 2	NM_015112	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The microtubule associated serine/threonine kinase 2 (EC:2.7.11.1) appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.In general involved in protein phosphorylation and spermatid differentiation.

In human this gene it seems to be slightly upregulated at 23 hours in the control and ebola infected, but earlier (3h) in Marburg infection. It seems to be expression of an intronic region.In bats this gene is also slightly upregulated at 3 hours of Marburg infection, in contrast with the control and Ebola infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	104	169	216	155	159	583	149	322	261
Read_Max	R. aegyptiacus	Transcriptome	62	43	39	49	57	71	27	77	52
Read_Max	R. aegyptiacus	Genome	248	194	117	163	167	116	88	300	271
DESeq	H. sapiens	Genome	2507.52	3721.5	2896.08	3037.5	3238.17	10119.13	2931.74	3758.75	4215.56
DESeq	R. aegyptiacus	Transcriptome	880.63	741.67	631.31	850.74	764.28	837.63	587.24	813.99	915.07
DESeq	R. aegyptiacus	Genome	4571.1	4226.64	3675.37	4399.24	4160.95	4554.58	3600.75	3897.33	4584.91

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2507.52	3037.5	2931.74	0.28	0.23	-0.05
7h	3721.5	3238.17	3758.75	-0.2	0.01	0.22
23h	2896.08	10119.13	4215.56	1.8	0.54	-1.26

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2507.52	3721.5	2896.08	0.57	0.21	-0.36
Ebov	3037.5	3238.17	10119.13	0.09	1.74	1.64
Marv	2931.74	3758.75	4215.56	0.36	0.52	0.17

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	880.63	850.74	587.24	-0.05	-0.58	-0.53
7h	741.67	764.28	813.99	0.04	0.13	0.09
23h	631.31	837.63	915.07	0.41	0.54	0.13

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	880.63	741.67	631.31	-0.25	-0.48	-0.23
Ebov	850.74	764.28	837.63	-0.15	-0.02	0.13
Marv	587.24	813.99	915.07	0.47	0.64	0.17

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material