MAST2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAST2 MAST205, MTSSK, KIAA0807 microtubule associated serine/threonine kinase 2 NM_015112 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The microtubule associated serine/threonine kinase 2 (EC:2.7.11.1) appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation.In general involved in protein phosphorylation and spermatid differentiation.

In human this gene it seems to be slightly upregulated at 23 hours in the control and ebola infected, but earlier (3h) in Marburg infection. It seems to be expression of an intronic region.In bats this gene is also slightly upregulated at 3 hours of Marburg infection, in contrast with the control and Ebola infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome104 169 216 155 159 583 149 322 261
Read_Max
batR. aegyptiacusTranscriptome 62 43 39 49 57 71 27 77 52
Read_Max
bat_genomeR. aegyptiacusGenome 248 194 117 163 167 116 88 300 271
DESeq
humanH. sapiensGenome 2507.52 3721.5 2896.08 3037.5 3238.17 10119.13 2931.74 3758.75 4215.56
DESeq
batR. aegyptiacusTranscriptome 880.63 741.67 631.31 850.74 764.28 837.63 587.24 813.99 915.07
DESeq
bat_genomeR. aegyptiacusGenome 4571.1 4226.64 3675.37 4399.24 4160.95 4554.58 3600.75 3897.33 4584.91

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2507.52 3037.5 2931.74 0.28 0.23 -0.05
7h 3721.5 3238.17 3758.75 -0.2 0.01 0.22
23h 2896.08 10119.13 4215.56 1.8 0.54 -1.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2507.52 3721.5 2896.08 0.57 0.21 -0.36
Ebov 3037.5 3238.17 10119.13 0.09 1.74 1.64
Marv 2931.74 3758.75 4215.56 0.36 0.52 0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 880.63 850.74 587.24 -0.05 -0.58 -0.53
7h 741.67 764.28 813.99 0.04 0.13 0.09
23h 631.31 837.63 915.07 0.41 0.54 0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 880.63 741.67 631.31 -0.25 -0.48 -0.23
Ebov 850.74 764.28 837.63 -0.15 -0.02 0.13
Marv 587.24 813.99 915.07 0.47 0.64 0.17