ATG4D

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ATG4D	APG4-D	autophagy related 4D, cysteine peptidase	NM_032885	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants.

This gene shows no specialities during EBOV/MARV infection in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	19	17	13	26	20	57	29	23	21
Read_Max	R. aegyptiacus	Transcriptome	18	17	9	14	14	14	14	16	19
Read_Max	R. aegyptiacus	Genome	44	37	35	66	44	39	31	61	81
DESeq	H. sapiens	Genome	153.22	146.84	112.2	202.9	127.01	389.2	155.39	153.68	166.28
DESeq	R. aegyptiacus	Transcriptome	116.94	99.94	88.95	87.07	110.51	126.75	113.35	106.75	110.34
DESeq	R. aegyptiacus	Genome	397.04	368.72	396.1	429.56	429.71	473.86	384.59	382.2	391.28

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	153.22	202.9	155.39	0.41	0.02	-0.38
7h	146.84	127.01	153.68	-0.21	0.07	0.27
23h	112.2	389.2	166.28	1.79	0.57	-1.23

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	153.22	146.84	112.2	-0.06	-0.45	-0.39
Ebov	202.9	127.01	389.2	-0.68	0.94	1.62
Marv	155.39	153.68	166.28	-0.02	0.1	0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	116.94	87.07	113.35	-0.43	-0.04	0.38
7h	99.94	110.51	106.75	0.15	0.1	-0.05
23h	88.95	126.75	110.34	0.51	0.31	-0.2

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	116.94	99.94	88.95	-0.23	-0.39	-0.17
Ebov	87.07	110.51	126.75	0.34	0.54	0.2
Marv	113.35	106.75	110.34	-0.09	-0.04	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material