FGF19

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FGF19 fibroblast growth factor 19 NM_005117 pdf NONE

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Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. The gene is 2 fold upregulated in EBOV 23h. The bat homolog is virtually not expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome91 114 78 81 89 276 123 207 163
Read_Max
batR. aegyptiacusTranscriptome NA 2 6 2 2 4 NA 3 24
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 998.54 919.91 694.98 888.45 720.46 2222.28 1282.6 1761.97 1945.18
DESeq
batR. aegyptiacusTranscriptome 1.0 4.63 14.44 2.83 3.19 6.13 1.0 7.61 32.49
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 998.54 888.45 1282.6 -0.17 0.36 0.53
7h 919.91 720.46 1761.97 -0.35 0.94 1.29
23h 694.98 2222.28 1945.18 1.68 1.48 -0.19

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 998.54 919.91 694.98 -0.12 -0.52 -0.4
Ebov 888.45 720.46 2222.28 -0.3 1.32 1.63
Marv 1282.6 1761.97 1945.18 0.46 0.6 0.14

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 2.83 1.0 1.5 0.0 -1.5
7h 4.63 3.19 7.61 -0.54 0.72 1.25
23h 14.44 6.13 32.49 -1.24 1.17 2.41

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 4.63 14.44 2.21 3.85 1.64
Ebov 2.83 3.19 6.13 0.17 1.12 0.94
Marv 1.0 7.61 32.49 2.93 5.02 2.09