EIF4EBP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EIF4EBP1 4E-BP1, 4EBP1, BP-1, PHAS-I,PHAS-I, 4E-BP1 eukaryotic translation initiation factor 4E binding protein 1 NM_004095 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Downregulated in human EBOV 23h. Bat homolog is up in MARV 23h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome97 111 107 102 128 58 124 169 134
Read_Max
batR. aegyptiacusTranscriptome 68 96 65 69 68 91 51 64 135
Read_Max
bat_genomeR. aegyptiacusGenome 93 61 57 77 42 53 43 69 133
DESeq
humanH. sapiensGenome 409.96 522.16 479.54 483.51 475.76 187.86 457.15 558.15 599.04
DESeq
batR. aegyptiacusTranscriptome 194.23 258.78 245.31 186.88 206.88 238.39 168.97 159.63 329.89
DESeq
bat_genomeR. aegyptiacusGenome 409.93 362.34 581.32 436.47 376.14 528.69 318.24 348.9 598.48

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 409.96 483.51 457.15 0.24 0.16 -0.08
7h 522.16 475.76 558.15 -0.13 0.1 0.23
23h 479.54 187.86 599.04 -1.35 0.32 1.67

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 409.96 522.16 479.54 0.35 0.23 -0.12
Ebov 483.51 475.76 187.86 -0.02 -1.36 -1.34
Marv 457.15 558.15 599.04 0.29 0.39 0.1

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 194.23 186.88 168.97 -0.06 -0.2 -0.15
7h 258.78 206.88 159.63 -0.32 -0.7 -0.37
23h 245.31 238.39 329.89 -0.04 0.43 0.47

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 194.23 258.78 245.31 0.41 0.34 -0.08
Ebov 186.88 206.88 238.39 0.15 0.35 0.2
Marv 168.97 159.63 329.89 -0.08 0.97 1.05