EIF4EBP1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
EIF4EBP1	4E-BP1, 4EBP1, BP-1, PHAS-I,PHAS-I, 4E-BP1	eukaryotic translation initiation factor 4E binding protein 1	NM_004095	pdf

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Description

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Downregulated in human EBOV 23h. Bat homolog is up in MARV 23h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	97	111	107	102	128	58	124	169	134
Read_Max	R. aegyptiacus	Transcriptome	68	96	65	69	68	91	51	64	135
Read_Max	R. aegyptiacus	Genome	93	61	57	77	42	53	43	69	133
DESeq	H. sapiens	Genome	409.96	522.16	479.54	483.51	475.76	187.86	457.15	558.15	599.04
DESeq	R. aegyptiacus	Transcriptome	194.23	258.78	245.31	186.88	206.88	238.39	168.97	159.63	329.89
DESeq	R. aegyptiacus	Genome	409.93	362.34	581.32	436.47	376.14	528.69	318.24	348.9	598.48

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	409.96	483.51	457.15	0.24	0.16	-0.08
7h	522.16	475.76	558.15	-0.13	0.1	0.23
23h	479.54	187.86	599.04	-1.35	0.32	1.67

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	409.96	522.16	479.54	0.35	0.23	-0.12
Ebov	483.51	475.76	187.86	-0.02	-1.36	-1.34
Marv	457.15	558.15	599.04	0.29	0.39	0.1

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	194.23	186.88	168.97	-0.06	-0.2	-0.15
7h	258.78	206.88	159.63	-0.32	-0.7	-0.37
23h	245.31	238.39	329.89	-0.04	0.43	0.47

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	194.23	258.78	245.31	0.41	0.34	-0.08
Ebov	186.88	206.88	238.39	0.15	0.35	0.2
Marv	168.97	159.63	329.89	-0.08	0.97	1.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material