TXNRD1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TXNRD1 GRIM-12, TR, TR1, TRXR1, TXNR,TXNR, GRIM-12, Trxr1 thioredoxin reductase 1 NM_003330 pdf NONE NONE

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Description

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Virtually no expression in human. The bat homolog is highly expressed and upregulated in Mearly MARV infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2122 1920 1873 2086 2570 2091 2966 4318 4834
Read_Max
batR. aegyptiacusTranscriptome 514 461 322 394 380 392 327 491 579
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 32209.32 28167.85 27435.72 33084.23 28911.97 26295.76 35935.7 48047.56 84388.9
DESeq
batR. aegyptiacusTranscriptome 4631.01 4622.05 3758.45 4066.57 4244.47 4324.04 4102.44 4165.09 4838.14
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 32209.32 33084.23 35935.7 0.04 0.16 0.12
7h 28167.85 28911.97 48047.56 0.04 0.77 0.73
23h 27435.72 26295.76 84388.9 -0.06 1.62 1.68

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 32209.32 28167.85 27435.72 -0.19 -0.23 -0.04
Ebov 33084.23 28911.97 26295.76 -0.19 -0.33 -0.14
Marv 35935.7 48047.56 84388.9 0.42 1.23 0.81

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4631.01 4066.57 4102.44 -0.19 -0.17 0.01
7h 4622.05 4244.47 4165.09 -0.12 -0.15 -0.03
23h 3758.45 4324.04 4838.14 0.2 0.36 0.16

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4631.01 4622.05 3758.45 -0.0 -0.3 -0.3
Ebov 4066.57 4244.47 4324.04 0.06 0.09 0.03
Marv 4102.44 4165.09 4838.14 0.02 0.24 0.22