FGA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FGA		fibrinogen alpha chain	NM_000508	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is the alpha component of fibrinogen, which is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Also, acts as a cofactor in platelet aggregation. Very low expression in bats, and highly express in humans. In both viral treatments in humans the expression of this genes decreases at least 3 folds.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4298	5142	4458	5045	7455	1979	6066	6349	2600
Read_Max	R. aegyptiacus	Transcriptome	11	8	6	15	12	9	17	11	10
Read_Max	R. aegyptiacus	Genome	0	0	0	0	0	0	0	0	0
DESeq	H. sapiens	Genome	46402.13	47672.92	41668.86	51624.9	50783.59	16418.45	50173.61	48284.96	25797.22
DESeq	R. aegyptiacus	Transcriptome	34.61	37.31	54.75	43.12	25.09	36.93	100.0	51.4	42.99
DESeq	R. aegyptiacus	Genome	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	46402.13	51624.9	50173.61	0.15	0.11	-0.04
7h	47672.92	50783.59	48284.96	0.09	0.02	-0.07
23h	41668.86	16418.45	25797.22	-1.34	-0.69	0.65

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	46402.13	47672.92	41668.86	0.04	-0.16	-0.19
Ebov	51624.9	50783.59	16418.45	-0.02	-1.65	-1.63
Marv	50173.61	48284.96	25797.22	-0.06	-0.96	-0.9

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	34.61	43.12	100.0	0.32	1.53	1.21
7h	37.31	25.09	51.4	-0.57	0.46	1.03
23h	54.75	36.93	42.99	-0.57	-0.35	0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	34.61	37.31	54.75	0.11	0.66	0.55
Ebov	43.12	25.09	36.93	-0.78	-0.22	0.56
Marv	100.0	51.4	42.99	-0.96	-1.22	-0.26

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

FGA