RAPGEF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RAPGEF1	RAPGEF1, C3G, GRF2,C3G	Rap guanine nucleotide exchange factor (GEF) 1	NM_005312	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1), transcript variant 2 gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

While the Mock human cells behave transcriptionally equal, during EBOV infection an 3X increase (as twice as much as in MARV infected samples) was seen. Furthermore, in bat cells after infection a upregulation could be observed in contrast to Mock.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	175	159	141	156	247	518	188	227	186
Read_Max	R. aegyptiacus	Transcriptome	233	260	153	207	203	289	211	251	247
Read_Max	R. aegyptiacus	Genome	319	234	136	254	179	178	209	308	295
DESeq	H. sapiens	Genome	4777.6	4577.17	3646.65	4634.45	4570.6	11461.37	4535.27	4976.96	5360.53
DESeq	R. aegyptiacus	Transcriptome	3794.23	3690.76	2681.05	3206.75	3354.17	4058.42	3937.81	3119.94	3364.26
DESeq	R. aegyptiacus	Genome	5115.09	4222.99	3820.42	5260.32	4589.54	5519.27	4998.55	3979.0	4566.93

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4777.6	4634.45	4535.27	-0.04	-0.08	-0.03
7h	4577.17	4570.6	4976.96	-0.0	0.12	0.12
23h	3646.65	11461.37	5360.53	1.65	0.56	-1.1

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4777.6	4577.17	3646.65	-0.06	-0.39	-0.33
Ebov	4634.45	4570.6	11461.37	-0.02	1.31	1.33
Marv	4535.27	4976.96	5360.53	0.13	0.24	0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3794.23	3206.75	3937.81	-0.24	0.05	0.3
7h	3690.76	3354.17	3119.94	-0.14	-0.24	-0.1
23h	2681.05	4058.42	3364.26	0.6	0.33	-0.27

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3794.23	3690.76	2681.05	-0.04	-0.5	-0.46
Ebov	3206.75	3354.17	4058.42	0.06	0.34	0.27
Marv	3937.81	3119.94	3364.26	-0.34	-0.23	0.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material