WASF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
WASF2 WAVE2, SCAR2 WAS protein family, member 2 NM_006990 pdf

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Description

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. WASF2 is almost 3 fold upregulated in 23h EBOV in human. The bat homolog is upregulated in MARV 23h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome191 211 239 213 287 955 215 289 329
Read_Max
batR. aegyptiacusTranscriptome 584 463 403 418 353 620 387 488 682
Read_Max
bat_genomeR. aegyptiacusGenome 609 398 332 428 298 337 316 520 700
DESeq
humanH. sapiensGenome 3847.04 3694.98 4069.6 3786.93 3689.36 11361.36 3439.64 3883.45 6248.9
DESeq
batR. aegyptiacusTranscriptome 3388.45 3097.13 3186.77 2924.73 2797.86 3842.85 3052.33 2836.55 3666.03
DESeq
bat_genomeR. aegyptiacusGenome 7919.28 6418.91 7062.87 7556.22 7062.9 9619.57 7934.7 6513.26 8828.19

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3847.04 3786.93 3439.64 -0.02 -0.16 -0.14
7h 3694.98 3689.36 3883.45 -0.0 0.07 0.07
23h 4069.6 11361.36 6248.9 1.48 0.62 -0.86

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3847.04 3694.98 4069.6 -0.06 0.08 0.14
Ebov 3786.93 3689.36 11361.36 -0.04 1.59 1.62
Marv 3439.64 3883.45 6248.9 0.18 0.86 0.69

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3388.45 2924.73 3052.33 -0.21 -0.15 0.06
7h 3097.13 2797.86 2836.55 -0.15 -0.13 0.02
23h 3186.77 3842.85 3666.03 0.27 0.2 -0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3388.45 3097.13 3186.77 -0.13 -0.09 0.04
Ebov 2924.73 2797.86 3842.85 -0.06 0.39 0.46
Marv 3052.33 2836.55 3666.03 -0.11 0.26 0.37