DSP

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DSP	DP,KPPS2, PPKS2, DPI, DPII	desmoplakin	NM_004415	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. There are several intronic regions that could be check for alternative splicing exons. There is a different pattern in ebola infected cells. The annotation in bats is incomplete.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	358	321	366	282	379	999	393	327	345
Read_Max	R. aegyptiacus	Transcriptome	4	3	4	13	2	2	2	3	16
Read_Max	R. aegyptiacus	Genome	5	8	4	3	2	3	3	4	14
DESeq	H. sapiens	Genome	13729.04	11299.15	13264.14	12217.72	11542.46	34765.03	12039.76	10303.83	14693.23
DESeq	R. aegyptiacus	Transcriptome	8.56	6.45	20.54	31.22	6.48	9.98	5.45	9.26	46.48
DESeq	R. aegyptiacus	Genome	15.47	33.77	35.7	11.85	14.51	35.25	14.62	19.03	202.06

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	13729.04	12217.72	12039.76	-0.17	-0.19	-0.02
7h	11299.15	11542.46	10303.83	0.03	-0.13	-0.16
23h	13264.14	34765.03	14693.23	1.39	0.15	-1.24

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	13729.04	11299.15	13264.14	-0.28	-0.05	0.23
Ebov	12217.72	11542.46	34765.03	-0.08	1.51	1.59
Marv	12039.76	10303.83	14693.23	-0.22	0.29	0.51

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8.56	31.22	5.45	1.87	-0.65	-2.52
7h	6.45	6.48	9.26	0.01	0.52	0.52
23h	20.54	9.98	46.48	-1.04	1.18	2.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8.56	6.45	20.54	-0.41	1.26	1.67
Ebov	31.22	6.48	9.98	-2.27	-1.65	0.62
Marv	5.45	9.26	46.48	0.76	3.09	2.33

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

DSP