SREBF2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SREBF2 | SREBP-2, bHLHd2,SREBP2 | sterol regulatory element binding transcription factor 2 | NM_004599 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants.
The gene is moderately expressed in all samples. The expression increases in human cells after infection with Ebola up to 2.5 times after 23 h. In contrast, its expression decreases from 7 h to 23 h after infection with Marburg virus. In bat cells, the expression increases after infection with both viruses. MIR33a is not expressed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 507 | 585 | 577 | 530 | 706 | 1615 | 625 | 887 | 472 |
Read_Max |  | R. aegyptiacus | Transcriptome | 446 | 428 | 403 | 378 | 308 | 702 | 366 | 457 | 617 |
Read_Max |  | R. aegyptiacus | Genome | 509 | 403 | 386 | 421 | 277 | 422 | 320 | 564 | 698 |
DESeq | | H. sapiens | Genome | 9501.43 | 9698.97 | 8803.38 | 10028.75 | 8677.62 | 25908.88 | 9846.75 | 10179.13 | 8674.77 |
DESeq | | R. aegyptiacus | Transcriptome | 5480.4 | 5466.2 | 6021.95 | 4792.69 | 4781.07 | 9191.15 | 5228.2 | 4296.46 | 6788.74 |
DESeq | | R. aegyptiacus | Genome | 7181.06 | 6604.19 | 8244.48 | 7811.0 | 6623.14 | 12582.85 | 6928.24 | 5851.15 | 9340.2 |