SRCAP

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SRCAP DOMO1, EAF1, FLHS, SWR1,KIAA0309, DOMO1 Snf2-related CREBBP activator protein NM_006662 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The Snf2-related CREBBP activator protein gene is involved in histone acetylation, regulation of transcription from RNA polymerase II promoter, ATP and DNA binding and helicase activity. It is a catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

It did not present any particularly interesting differential expression pattern in the samples analyzed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome199 233 171 228 270 431 238 255 164
Read_Max
batR. aegyptiacusTranscriptome 188 202 133 177 156 133 138 166 161
Read_Max
bat_genomeR. aegyptiacusGenome 209 165 114 203 126 82 127 212 190
DESeq
humanH. sapiensGenome 8637.85 8231.37 6107.86 8393.01 6863.12 15797.33 8081.81 7762.69 5555.17
DESeq
batR. aegyptiacusTranscriptome 6655.75 6908.52 5445.39 6130.48 6396.33 5238.95 6432.93 5216.85 5076.93
DESeq
bat_genomeR. aegyptiacusGenome 7499.9 6739.27 5789.77 8200.06 7042.8 5841.71 6999.09 5636.26 5602.06

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8637.85 8393.01 8081.81 -0.04 -0.1 -0.05
7h 8231.37 6863.12 7762.69 -0.26 -0.08 0.18
23h 6107.86 15797.33 5555.17 1.37 -0.14 -1.51

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8637.85 8231.37 6107.86 -0.07 -0.5 -0.43
Ebov 8393.01 6863.12 15797.33 -0.29 0.91 1.2
Marv 8081.81 7762.69 5555.17 -0.06 -0.54 -0.48

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6655.75 6130.48 6432.93 -0.12 -0.05 0.07
7h 6908.52 6396.33 5216.85 -0.11 -0.41 -0.29
23h 5445.39 5238.95 5076.93 -0.06 -0.1 -0.05

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6655.75 6908.52 5445.39 0.05 -0.29 -0.34
Ebov 6130.48 6396.33 5238.95 0.06 -0.23 -0.29
Marv 6432.93 5216.85 5076.93 -0.3 -0.34 -0.04