SRCAP

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SRCAP	DOMO1, EAF1, FLHS, SWR1,KIAA0309, DOMO1	Snf2-related CREBBP activator protein	NM_006662	pdf

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Description

The Snf2-related CREBBP activator protein gene is involved in histone acetylation, regulation of transcription from RNA polymerase II promoter, ATP and DNA binding and helicase activity. It is a catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.

It did not present any particularly interesting differential expression pattern in the samples analyzed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	199	233	171	228	270	431	238	255	164
Read_Max	R. aegyptiacus	Transcriptome	188	202	133	177	156	133	138	166	161
Read_Max	R. aegyptiacus	Genome	209	165	114	203	126	82	127	212	190
DESeq	H. sapiens	Genome	8637.85	8231.37	6107.86	8393.01	6863.12	15797.33	8081.81	7762.69	5555.17
DESeq	R. aegyptiacus	Transcriptome	6655.75	6908.52	5445.39	6130.48	6396.33	5238.95	6432.93	5216.85	5076.93
DESeq	R. aegyptiacus	Genome	7499.9	6739.27	5789.77	8200.06	7042.8	5841.71	6999.09	5636.26	5602.06

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8637.85	8393.01	8081.81	-0.04	-0.1	-0.05
7h	8231.37	6863.12	7762.69	-0.26	-0.08	0.18
23h	6107.86	15797.33	5555.17	1.37	-0.14	-1.51

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8637.85	8231.37	6107.86	-0.07	-0.5	-0.43
Ebov	8393.01	6863.12	15797.33	-0.29	0.91	1.2
Marv	8081.81	7762.69	5555.17	-0.06	-0.54	-0.48

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6655.75	6130.48	6432.93	-0.12	-0.05	0.07
7h	6908.52	6396.33	5216.85	-0.11	-0.41	-0.29
23h	5445.39	5238.95	5076.93	-0.06	-0.1	-0.05

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6655.75	6908.52	5445.39	0.05	-0.29	-0.34
Ebov	6130.48	6396.33	5238.95	0.06	-0.23	-0.29
Marv	6432.93	5216.85	5076.93	-0.3	-0.34	-0.04

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material