MCM2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MCM2	BM28, CCNL1, CDCL1, D3S3194, MITOTIN, cdc19,D3S3194, KIAA0030, BM28	minichromosome maintenance complex component 2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The minichromosome maintenance complex component 2 (EC:3.6.4.12) gene is involved in DNA replication and cell cycle. This gene seems to be downregulated after 7 hours of viral infection (ebola and marburg) in humans, and also seems to be downregulated in bats infected with ebola after 3 hours.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	574	768	485	785	786	354	1162	1107	326
Read_Max	R. aegyptiacus	Transcriptome	763	623	284	463	430	510	430	538	472
Read_Max	R. aegyptiacus	Genome	856	499	251	590	373	300	367	666	535
DESeq	H. sapiens	Genome	9913.44	11595.94	8752.75	13960.68	10127.93	4938.34	13758.2	12133.54	5421.42
DESeq	R. aegyptiacus	Transcriptome	7694.17	8053.12	4403.42	6163.45	6214.54	6470.8	6784.45	5931.52	5049.82
DESeq	R. aegyptiacus	Genome	8098.03	6445.38	4333.68	8910.06	6712.43	6871.68	7264.48	6190.53	5255.3

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	9913.44	13960.68	13758.2	0.49	0.47	-0.02
7h	11595.94	10127.93	12133.54	-0.2	0.07	0.26
23h	8752.75	4938.34	5421.42	-0.83	-0.69	0.13

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	9913.44	11595.94	8752.75	0.23	-0.18	-0.41
Ebov	13960.68	10127.93	4938.34	-0.46	-1.5	-1.04
Marv	13758.2	12133.54	5421.42	-0.18	-1.34	-1.16

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7694.17	6163.45	6784.45	-0.32	-0.18	0.14
7h	8053.12	6214.54	5931.52	-0.37	-0.44	-0.07
23h	4403.42	6470.8	5049.82	0.56	0.2	-0.36

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7694.17	8053.12	4403.42	0.07	-0.81	-0.87
Ebov	6163.45	6214.54	6470.8	0.01	0.07	0.06
Marv	6784.45	5931.52	5049.82	-0.19	-0.43	-0.23

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material