HNF4A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
HNF4A	HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14,NR2A1, HNF4	hepatocyte nuclear factor 4, alpha		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The hepatocyte nuclear factor 4, alpha gene is involved in the AMPK signaling pathway and in the Maturity onset diabetes of the young. This gene seems to be slightly downregulated after 23 hours of viral infection (Marburg and Ebola) in human samples. It was not expressed in bats.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	387	511	369	423	550	237	509	645	318
Read_Max	R. aegyptiacus	Transcriptome	3	4	3	2	NA	2	2	NA	2
Read_Max	R. aegyptiacus	Genome	2	0	0	1	0	1	0	0	0
DESeq	H. sapiens	Genome	10182.36	10652.55	7477.96	10429.13	9693.0	3696.11	10368.68	10725.09	6510.95
DESeq	R. aegyptiacus	Transcriptome	5.2	5.54	8.33	5.58	1.0	6.13	4.34	1.0	6.25
DESeq	R. aegyptiacus	Genome	1.72	0.0	0.0	1.97	0.0	1.31	0.0	0.0	0.0

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	10182.36	10429.13	10368.68	0.03	0.03	-0.01
7h	10652.55	9693.0	10725.09	-0.14	0.01	0.15
23h	7477.96	3696.11	6510.95	-1.02	-0.2	0.82

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	10182.36	10652.55	7477.96	0.07	-0.45	-0.51
Ebov	10429.13	9693.0	3696.11	-0.11	-1.5	-1.39
Marv	10368.68	10725.09	6510.95	0.05	-0.67	-0.72

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5.2	5.58	4.34	0.1	-0.26	-0.36
7h	5.54	1.0	1.0	-2.47	-2.47	0.0
23h	8.33	6.13	6.25	-0.44	-0.41	0.03

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5.2	5.54	8.33	0.09	0.68	0.59
Ebov	5.58	1.0	6.13	-2.48	0.14	2.62
Marv	4.34	1.0	6.25	-2.12	0.53	2.64

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material