RNF40

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RNF40	BRE1B, RBP95, STARING,KIAA0661, BRE1B	ring finger protein 40, E3 ubiquitin protein ligase	NM_014771	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The ring finger protein 40, E3 ubiquitin protein ligase (EC:6.3.2.-) is involved in protein modification, particularly protein ubiquitination. Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.

It seems to be slightly upregulated during ebola infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	128	182	204	136	224	502	192	265	169
Read_Max	R. aegyptiacus	Transcriptome	53	50	58	58	46	72	37	71	82
Read_Max	R. aegyptiacus	Genome	193	198	179	161	136	156	95	260	322
DESeq	H. sapiens	Genome	2390.82	3443.07	2986.42	3209.74	3023.55	8336.05	3291.4	3986.56	2954.23
DESeq	R. aegyptiacus	Transcriptome	845.34	944.09	1130.92	974.36	980.01	1366.31	706.27	985.84	1050.65
DESeq	R. aegyptiacus	Genome	3180.6	3564.95	4177.47	3680.35	3666.5	5409.62	2701.13	3703.85	4054.07

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2390.82	3209.74	3291.4	0.42	0.46	0.04
7h	3443.07	3023.55	3986.56	-0.19	0.21	0.4
23h	2986.42	8336.05	2954.23	1.48	-0.02	-1.5

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2390.82	3443.07	2986.42	0.53	0.32	-0.21
Ebov	3209.74	3023.55	8336.05	-0.09	1.38	1.46
Marv	3291.4	3986.56	2954.23	0.28	-0.16	-0.43

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	845.34	974.36	706.27	0.2	-0.26	-0.46
7h	944.09	980.01	985.84	0.05	0.06	0.01
23h	1130.92	1366.31	1050.65	0.27	-0.11	-0.38

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	845.34	944.09	1130.92	0.16	0.42	0.26
Ebov	974.36	980.01	1366.31	0.01	0.49	0.48
Marv	706.27	985.84	1050.65	0.48	0.57	0.09

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material