KDM5C

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
KDM5C	DXS1272E, JARID1C, MRX13, MRXJ, MRXSCJ, MRXSJ, SMCX, XE169	lysine (K)-specific demethylase 5C	NM_004187	pdf

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Description

The histone demethylase JARID1 [EC:1.14.11.-] gene is involved in transcription, DNA-binding, histone H3-K4 demethylation and zinc ion binding. It is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

It did not present any particularly interesting differential expression pattern in the samples analyzed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	361	518	382	445	552	1178	522	776	382
Read_Max	R. aegyptiacus	Transcriptome	89	92	68	70	62	86	45	78	97
Read_Max	R. aegyptiacus	Genome	208	211	142	163	153	126	88	286	203
DESeq	H. sapiens	Genome	7997.52	9950.88	8450.93	8791.1	8352.44	22036.12	8786.21	9831.41	7788.58
DESeq	R. aegyptiacus	Transcriptome	1225.92	1282.66	1510.82	1202.36	1310.73	1665.29	971.02	1224.61	1355.92
DESeq	R. aegyptiacus	Genome	3662.72	3858.83	4642.75	4149.41	4060.49	5555.82	3153.19	3824.38	4345.17

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7997.52	8791.1	8786.21	0.14	0.14	-0.0
7h	9950.88	8352.44	9831.41	-0.25	-0.02	0.24
23h	8450.93	22036.12	7788.58	1.38	-0.12	-1.5

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7997.52	9950.88	8450.93	0.32	0.08	-0.24
Ebov	8791.1	8352.44	22036.12	-0.07	1.33	1.4
Marv	8786.21	9831.41	7788.58	0.16	-0.17	-0.34

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1225.92	1202.36	971.02	-0.03	-0.34	-0.31
7h	1282.66	1310.73	1224.61	0.03	-0.07	-0.1
23h	1510.82	1665.29	1355.92	0.14	-0.16	-0.3

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1225.92	1282.66	1510.82	0.07	0.3	0.24
Ebov	1202.36	1310.73	1665.29	0.12	0.47	0.35
Marv	971.02	1224.61	1355.92	0.33	0.48	0.15

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material