DOT1L

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DOT1L	DOT1, KMT4,KIAA1814, DOT1	DOT1-like histone H3K79 methyltransferase	NM_032482	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The DOT1-like histone H3K79 methyltransferase (EC:2.1.1.43) gene is involved in Lysine degradation and Transcriptional misregulation in cancer. It seems to be slightly upregulated in human during ebola infection.

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max		H. sapiens	Genome	115	154	159	122	203	405	163	235	156
Read_Max		R. aegyptiacus	Transcriptome	55	40	33	54	38	48	38	44	90
Read_Max		R. aegyptiacus	Genome	113	88	52	74	62	60	65	108	121
DESeq		H. sapiens	Genome	3923.15	4672.02	4333.69	3899.85	4641.32	10716.55	4075.62	5514.92	4746.18
DESeq		R. aegyptiacus	Transcriptome	431.15	359.54	373.57	461.58	457.65	423.17	378.11	378.58	518.83
DESeq		R. aegyptiacus	Genome	2269.65	2121.08	1915.79	2147.78	2379.6	2537.72	2189.46	1937.96	2439.29

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3923.15	3899.85	4075.62	-0.01	0.06	0.06
7h	4672.02	4641.32	5514.92	-0.01	0.24	0.25
23h	4333.69	10716.55	4746.18	1.31	0.13	-1.18

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3923.15	4672.02	4333.69	0.25	0.14	-0.11
Ebov	3899.85	4641.32	10716.55	0.25	1.46	1.21
Marv	4075.62	5514.92	4746.18	0.44	0.22	-0.22

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	431.15	461.58	378.11	0.1	-0.19	-0.29
7h	359.54	457.65	378.58	0.35	0.07	-0.27
23h	373.57	423.17	518.83	0.18	0.47	0.29

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	431.15	359.54	373.57	-0.26	-0.21	0.06
Ebov	461.58	457.65	423.17	-0.01	-0.13	-0.11
Marv	378.11	378.58	518.83	0.0	0.46	0.45