MAPK14

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAPK14 B5TY32, p38alpha,p38,PRKM14, p38, Mxi2, PRKM15 mitogen-activated protein kinase 14 NM_001315 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

MAP14 gene was expressed, but no abnormalities were observed.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome168 163 178 176 214 192 210 205 162
Read_Max
batR. aegyptiacusTranscriptome 228 197 175 214 146 259 196 211 239
Read_Max
bat_genomeR. aegyptiacusGenome 265 224 149 195 144 156 198 272 280
DESeq
humanH. sapiensGenome 3150.9 2923.96 3305.12 3466.4 3121.92 2388.08 3237.01 2890.65 3186.93
DESeq
batR. aegyptiacusTranscriptome 828.54 798.86 678.95 766.5 700.76 864.58 834.19 722.28 822.35
DESeq
bat_genomeR. aegyptiacusGenome 3965.23 3468.2 3047.19 3670.48 3771.42 4028.5 4459.89 3719.71 3977.87

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3150.9 3466.4 3237.01 0.14 0.04 -0.1
7h 2923.96 3121.92 2890.65 0.09 -0.02 -0.11
23h 3305.12 2388.08 3186.93 -0.47 -0.05 0.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3150.9 2923.96 3305.12 -0.11 0.07 0.18
Ebov 3466.4 3121.92 2388.08 -0.15 -0.54 -0.39
Marv 3237.01 2890.65 3186.93 -0.16 -0.02 0.14

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 828.54 766.5 834.19 -0.11 0.01 0.12
7h 798.86 700.76 722.28 -0.19 -0.15 0.04
23h 678.95 864.58 822.35 0.35 0.28 -0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 828.54 798.86 678.95 -0.05 -0.29 -0.23
Ebov 766.5 700.76 864.58 -0.13 0.17 0.3
Marv 834.19 722.28 822.35 -0.21 -0.02 0.19