ISG15

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ISG15 G1P2, IP17, UCRP, ENSG00000187608,IFI15 ISG15 ubiquitin-like modifier NM_005101 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a ubiquitin-like protein that isconjugated to intracellular target proteins upon activation byinterferon-alpha and interferon-beta. Several functions have been ascribedto the encoded protein, including chemotactic activity towards neutrophils,direction of ligated target proteins to intermediate filaments, cell-to-cellsignaling, and antiviral activity during viral infections. While conjugatesof this protein have been found to be noncovalently attached to intermediatefilaments, this protein is sometimes secreted.

Almost no expression was observed throughout all samples. The Ebola virus23 h human cells sample was slightly higher expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome6 8 6 11 8 18 7 9 11
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 34 25 22 35 19 14 25 47 42
DESeq
humanH. sapiensGenome 16.22 23.44 16.89 28.38 20.51 32.58 14.16 28.18 14.05
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 75.63 55.67 81.45 98.75 70.32 57.44 73.09 67.4 73.63

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 16.22 28.38 14.16 0.81 -0.2 -1.0
7h 23.44 20.51 28.18 -0.19 0.27 0.46
23h 16.89 32.58 14.05 0.95 -0.27 -1.21

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 16.22 23.44 16.89 0.53 0.06 -0.47
Ebov 28.38 20.51 32.58 -0.47 0.2 0.67
Marv 14.16 28.18 14.05 0.99 -0.01 -1.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA