VPS41

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
VPS41	HVPS41,HVSP41	vacuolar protein sorting 41 homolog (S. cerevisiae)		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi.

Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. The gene is slightly upregulated in human cells and bat cells after 7h and 23h of infection with the Ebola and Marbug viruses. In addition, significant expression is visible in human cells between exons 7--8 (total 28 exons).

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	171	212	169	175	283	184	185	265	203
Read_Max	R. aegyptiacus	Transcriptome	280	255	164	279	289	214	232	283	252
Read_Max	R. aegyptiacus	Genome	296	275	138	230	167	123	184	328	243
DESeq	H. sapiens	Genome	2507.52	2461.95	2748.15	2432.94	2643.9	2965.77	2184.36	2243.98	3198.89
DESeq	R. aegyptiacus	Transcriptome	3211.18	2852.05	3048.73	3684.73	3717.74	3487.4	3596.3	3446.29	3359.01
DESeq	R. aegyptiacus	Genome	3435.84	3480.98	3024.87	3175.75	3458.9	3656.45	3660.35	3324.03	3188.46

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2507.52	2432.94	2184.36	-0.04	-0.2	-0.16
7h	2461.95	2643.9	2243.98	0.1	-0.13	-0.24
23h	2748.15	2965.77	3198.89	0.11	0.22	0.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2507.52	2461.95	2748.15	-0.03	0.13	0.16
Ebov	2432.94	2643.9	2965.77	0.12	0.29	0.17
Marv	2184.36	2243.98	3198.89	0.04	0.55	0.51

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3211.18	3684.73	3596.3	0.2	0.16	-0.04
7h	2852.05	3717.74	3446.29	0.38	0.27	-0.11
23h	3048.73	3487.4	3359.01	0.19	0.14	-0.05

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3211.18	2852.05	3048.73	-0.17	-0.07	0.1
Ebov	3684.73	3717.74	3487.4	0.01	-0.08	-0.09
Marv	3596.3	3446.29	3359.01	-0.06	-0.1	-0.04

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material