VPS41

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VPS41 HVPS41,HVSP41 vacuolar protein sorting 41 homolog (S. cerevisiae) pdf

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Description

The vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi.

Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. The gene is slightly upregulated in human cells and bat cells after 7h and 23h of infection with the Ebola and Marbug viruses. In addition, significant expression is visible in human cells between exons 7--8 (total 28 exons).

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome171 212 169 175 283 184 185 265 203
Read_Max
batR. aegyptiacusTranscriptome 280 255 164 279 289 214 232 283 252
Read_Max
bat_genomeR. aegyptiacusGenome 296 275 138 230 167 123 184 328 243
DESeq
humanH. sapiensGenome 2507.52 2461.95 2748.15 2432.94 2643.9 2965.77 2184.36 2243.98 3198.89
DESeq
batR. aegyptiacusTranscriptome 3211.18 2852.05 3048.73 3684.73 3717.74 3487.4 3596.3 3446.29 3359.01
DESeq
bat_genomeR. aegyptiacusGenome 3435.84 3480.98 3024.87 3175.75 3458.9 3656.45 3660.35 3324.03 3188.46

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2507.52 2432.94 2184.36 -0.04 -0.2 -0.16
7h 2461.95 2643.9 2243.98 0.1 -0.13 -0.24
23h 2748.15 2965.77 3198.89 0.11 0.22 0.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2507.52 2461.95 2748.15 -0.03 0.13 0.16
Ebov 2432.94 2643.9 2965.77 0.12 0.29 0.17
Marv 2184.36 2243.98 3198.89 0.04 0.55 0.51

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3211.18 3684.73 3596.3 0.2 0.16 -0.04
7h 2852.05 3717.74 3446.29 0.38 0.27 -0.11
23h 3048.73 3487.4 3359.01 0.19 0.14 -0.05

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3211.18 2852.05 3048.73 -0.17 -0.07 0.1
Ebov 3684.73 3717.74 3487.4 0.01 -0.08 -0.09
Marv 3596.3 3446.29 3359.01 -0.06 -0.1 -0.04