PPP1CA

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PPP1CA PP1A, PP-1A, PP1alpha protein phosphatase 1, catalytic subunit, alpha isozyme NM_002708 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

he protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory.

Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. Only the small isoform containing exons 14 to 17 seems to be expressed in bat cells and highly in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1386 1250 1157 1166 1314 1901 1470 1624 1237
Read_Max
batR. aegyptiacusTranscriptome 269 263 196 199 168 261 203 230 234
Read_Max
bat_genomeR. aegyptiacusGenome 354 277 212 308 194 175 197 329 362
DESeq
humanH. sapiensGenome 8691.63 7278.81 5952.98 7145.1 6018.46 9667.76 7380.05 7061.66 6719.72
DESeq
batR. aegyptiacusTranscriptome 1044.45 1046.66 1086.95 861.73 838.74 1176.39 1068.91 851.17 1027.91
DESeq
bat_genomeR. aegyptiacusGenome 2131.29 1760.57 1998.36 2313.67 1803.67 2447.64 2164.72 1719.9 2074.55

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8691.63 7145.1 7380.05 -0.28 -0.24 0.05
7h 7278.81 6018.46 7061.66 -0.27 -0.04 0.23
23h 5952.98 9667.76 6719.72 0.7 0.17 -0.52

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8691.63 7278.81 5952.98 -0.26 -0.55 -0.29
Ebov 7145.1 6018.46 9667.76 -0.25 0.44 0.68
Marv 7380.05 7061.66 6719.72 -0.06 -0.14 -0.07

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1044.45 861.73 1068.91 -0.28 0.03 0.31
7h 1046.66 838.74 851.17 -0.32 -0.3 0.02
23h 1086.95 1176.39 1027.91 0.11 -0.08 -0.19

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1044.45 1046.66 1086.95 0.0 0.06 0.05
Ebov 861.73 838.74 1176.39 -0.04 0.45 0.49
Marv 1068.91 851.17 1027.91 -0.33 -0.06 0.27