ATF6B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ATF6B Alpha,G13 activating transcription factor 6 beta pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

This gene was neither expressed in human cells nor in bat cells cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome70 102 94 96 104 93 118 163 57
Read_Max
batR. aegyptiacusTranscriptome 186 155 119 178 149 119 96 189 189
Read_Max
bat_genomeR. aegyptiacusGenome 198 219 147 165 116 67 80 271 213
DESeq
humanH. sapiensGenome 792.53 1175.89 917.38 1105.18 939.15 930.04 1067.68 1289.55 783.89
DESeq
batR. aegyptiacusTranscriptome 1296.5 1601.26 1496.16 1561.3 1306.35 1132.77 796.37 1421.25 1525.62
DESeq
bat_genomeR. aegyptiacusGenome 1360.41 1660.17 1591.1 1783.4 1334.9 1131.79 887.26 1495.5 1532.58

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 792.53 1105.18 1067.68 0.48 0.43 -0.05
7h 1175.89 939.15 1289.55 -0.32 0.13 0.46
23h 917.38 930.04 783.89 0.02 -0.23 -0.25

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 792.53 1175.89 917.38 0.57 0.21 -0.36
Ebov 1105.18 939.15 930.04 -0.23 -0.25 -0.01
Marv 1067.68 1289.55 783.89 0.27 -0.45 -0.72

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1296.5 1561.3 796.37 0.27 -0.7 -0.97
7h 1601.26 1306.35 1421.25 -0.29 -0.17 0.12
23h 1496.16 1132.77 1525.62 -0.4 0.03 0.43

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1296.5 1601.26 1496.16 0.3 0.21 -0.1
Ebov 1561.3 1306.35 1132.77 -0.26 -0.46 -0.21
Marv 796.37 1421.25 1525.62 0.84 0.94 0.1