ATF6B

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ATF6B	Alpha,G13	activating transcription factor 6 beta		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

This gene was neither expressed in human cells nor in bat cells cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	70	102	94	96	104	93	118	163	57
Read_Max	R. aegyptiacus	Transcriptome	186	155	119	178	149	119	96	189	189
Read_Max	R. aegyptiacus	Genome	198	219	147	165	116	67	80	271	213
DESeq	H. sapiens	Genome	792.53	1175.89	917.38	1105.18	939.15	930.04	1067.68	1289.55	783.89
DESeq	R. aegyptiacus	Transcriptome	1296.5	1601.26	1496.16	1561.3	1306.35	1132.77	796.37	1421.25	1525.62
DESeq	R. aegyptiacus	Genome	1360.41	1660.17	1591.1	1783.4	1334.9	1131.79	887.26	1495.5	1532.58

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	792.53	1105.18	1067.68	0.48	0.43	-0.05
7h	1175.89	939.15	1289.55	-0.32	0.13	0.46
23h	917.38	930.04	783.89	0.02	-0.23	-0.25

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	792.53	1175.89	917.38	0.57	0.21	-0.36
Ebov	1105.18	939.15	930.04	-0.23	-0.25	-0.01
Marv	1067.68	1289.55	783.89	0.27	-0.45	-0.72

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1296.5	1561.3	796.37	0.27	-0.7	-0.97
7h	1601.26	1306.35	1421.25	-0.29	-0.17	0.12
23h	1496.16	1132.77	1525.62	-0.4	0.03	0.43

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1296.5	1601.26	1496.16	0.3	0.21	-0.1
Ebov	1561.3	1306.35	1132.77	-0.26	-0.46	-0.21
Marv	796.37	1421.25	1525.62	0.84	0.94	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material