VPS18

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VPS18 KIAA1475, PEP3 vacuolar protein sorting 18 homolog (S. cerevisiae) pdf

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Description

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.

This gene shows no change in the expression pattern, but an additional splice variant in human cells cells three hours after infection with the Ebola virus.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome52 41 39 59 55 83 67 78 51
Read_Max
batR. aegyptiacusTranscriptome 60 58 36 55 43 34 41 60 59
Read_Max
bat_genomeR. aegyptiacusGenome 90 72 52 85 50 31 44 68 64
DESeq
humanH. sapiensGenome 932.57 853.61 677.11 993.39 679.81 1339.29 968.56 933.84 1012.23
DESeq
batR. aegyptiacusTranscriptome 726.04 798.86 616.65 663.94 681.05 478.34 698.48 632.22 619.42
DESeq
bat_genomeR. aegyptiacusGenome 940.17 776.69 759.84 1021.06 814.78 659.23 887.26 745.37 765.44

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 932.57 993.39 968.56 0.09 0.05 -0.04
7h 853.61 679.81 933.84 -0.33 0.13 0.46
23h 677.11 1339.29 1012.23 0.98 0.58 -0.4

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 932.57 853.61 677.11 -0.13 -0.46 -0.33
Ebov 993.39 679.81 1339.29 -0.55 0.43 0.98
Marv 968.56 933.84 1012.23 -0.05 0.06 0.12

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 726.04 663.94 698.48 -0.13 -0.06 0.07
7h 798.86 681.05 632.22 -0.23 -0.34 -0.11
23h 616.65 478.34 619.42 -0.37 0.01 0.37

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 726.04 798.86 616.65 0.14 -0.24 -0.37
Ebov 663.94 681.05 478.34 0.04 -0.47 -0.51
Marv 698.48 632.22 619.42 -0.14 -0.17 -0.03