PIK3C2A

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2,PI3-K-C2A,PI3K-C2alpha	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	NM_002645	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

There is a small (<10) number of transcripts within a human cells intron.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	147	209	217	138	270	284	151	222	179
Read_Max	R. aegyptiacus	Transcriptome	329	280	244	354	265	286	289	325	321
Read_Max	R. aegyptiacus	Genome	357	351	201	262	232	199	242	396	394
DESeq	H. sapiens	Genome	4413.29	5351.25	6227.0	4140.54	6028.22	7424.12	3759.82	4378.24	5934.65
DESeq	R. aegyptiacus	Transcriptome	6226.44	4915.23	4944.56	7021.43	7409.28	6718.46	6780.0	6619.76	5291.24
DESeq	R. aegyptiacus	Genome	6899.18	7327.03	5139.27	5797.52	8019.42	7634.04	7622.08	7075.46	5996.77

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4413.29	4140.54	3759.82	-0.09	-0.23	-0.14
7h	5351.25	6028.22	4378.24	0.17	-0.29	-0.46
23h	6227.0	7424.12	5934.65	0.25	-0.07	-0.32

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4413.29	5351.25	6227.0	0.28	0.5	0.22
Ebov	4140.54	6028.22	7424.12	0.54	0.84	0.3
Marv	3759.82	4378.24	5934.65	0.22	0.66	0.44

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6226.44	7021.43	6780.0	0.17	0.12	-0.05
7h	4915.23	7409.28	6619.76	0.59	0.43	-0.16
23h	4944.56	6718.46	5291.24	0.44	0.1	-0.34

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6226.44	4915.23	4944.56	-0.34	-0.33	0.01
Ebov	7021.43	7409.28	6718.46	0.08	-0.06	-0.14
Marv	6780.0	6619.76	5291.24	-0.03	-0.36	-0.32

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material