Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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JAK1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
JAK1	JAK1A, JTK3	Janus kinase 1	NM_002227	pdf

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Description

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosinekinases (PTK) characterized by the presence of a secondphosphotransferase-related domain immediately N-terminal to the PTK domain.The second phosphotransferase domain bears all the hallmarks of a proteinkinase, although its structure differs significantly from that of the PTKand threonine/serine kinase family members. JAK1 is a large, widelyexpressed membrane-associated phosphoprotein. JAK1 is involved in theinterferon-alpha/beta and -gamma signal transduction pathways. Thereciprocal interdependence between JAK1 and TYK2 activities in theinterferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gammapathway, may reflect a requirement for these kinases in the correct assemblyof interferon receptor complexes. These kinases couple cytokine ligandbinding to tyrosine phosphorylation of various known signaling proteins andof a unique family of transcription factors termed the signal transducersand activators of transcription, or STATs.

This gene is expressed in human cells and bat cells in all probes. While theexpression is lower at later timepoints in the uninfected probes, it isslightly upregulated in Ebola and Marburg infected probes.

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