JAK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
JAK1 JAK1A, JTK3 Janus kinase 1 NM_002227 pdf

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Description

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosinekinases (PTK) characterized by the presence of a secondphosphotransferase-related domain immediately N-terminal to the PTK domain.The second phosphotransferase domain bears all the hallmarks of a proteinkinase, although its structure differs significantly from that of the PTKand threonine/serine kinase family members. JAK1 is a large, widelyexpressed membrane-associated phosphoprotein. JAK1 is involved in theinterferon-alpha/beta and -gamma signal transduction pathways. Thereciprocal interdependence between JAK1 and TYK2 activities in theinterferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gammapathway, may reflect a requirement for these kinases in the correct assemblyof interferon receptor complexes. These kinases couple cytokine ligandbinding to tyrosine phosphorylation of various known signaling proteins andof a unique family of transcription factors termed the signal transducersand activators of transcription, or STATs.

This gene is expressed in human cells and bat cells in all probes. While theexpression is lower at later timepoints in the uninfected probes, it isslightly upregulated in Ebola and Marburg infected probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome241 254 205 249 341 366 314 324 288
Read_Max
batR. aegyptiacusTranscriptome 608 438 328 452 402 644 414 497 587
Read_Max
bat_genomeR. aegyptiacusGenome 657 483 283 397 326 386 355 589 644
DESeq
humanH. sapiensGenome 6803.12 5643.96 4354.54 6355.75 5585.97 7488.6 6272.14 5425.39 6185.83
DESeq
batR. aegyptiacusTranscriptome 10956.43 8747.5 7572.08 8754.79 9252.32 11807.55 10843.62 8574.57 9061.23
DESeq
bat_genomeR. aegyptiacusGenome 12347.72 9672.63 7875.16 10414.0 10545.23 13854.32 12552.03 9328.22 10183.54

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6803.12 6355.75 6272.14 -0.1 -0.12 -0.02
7h 5643.96 5585.97 5425.39 -0.01 -0.06 -0.04
23h 4354.54 7488.6 6185.83 0.78 0.51 -0.28

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6803.12 5643.96 4354.54 -0.27 -0.64 -0.37
Ebov 6355.75 5585.97 7488.6 -0.19 0.24 0.42
Marv 6272.14 5425.39 6185.83 -0.21 -0.02 0.19

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10956.43 8754.79 10843.62 -0.32 -0.01 0.31
7h 8747.5 9252.32 8574.57 0.08 -0.03 -0.11
23h 7572.08 11807.55 9061.23 0.64 0.26 -0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10956.43 8747.5 7572.08 -0.32 -0.53 -0.21
Ebov 8754.79 9252.32 11807.55 0.08 0.43 0.35
Marv 10843.62 8574.57 9061.23 -0.34 -0.26 0.08