TIRAP

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TIRAP	BACTS1, MAL,Mal, wyatt	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	NM_148910	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

The gene is about 3 fold downregulated in the human cells 23h Ebola but not in the Marburg samples. Alas, the mapping of the bat cells genome did not work for this gene.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	49	38	36	36	36	11	39	35	26
Read_Max	R. aegyptiacus	Transcriptome	17	27	11	24	21	12	18	34	24
Read_Max	R. aegyptiacus	Genome	41	30	29	31	18	16	26	40	35
DESeq	H. sapiens	Genome	472.88	373.25	345.51	407.08	353.82	89.17	410.65	346.32	354.39
DESeq	R. aegyptiacus	Transcriptome	75.77	100.85	81.62	117.29	96.27	58.74	121.14	102.62	101.59
DESeq	R. aegyptiacus	Genome	377.27	514.75	430.69	437.46	398.46	335.49	513.91	449.6	410.12

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	472.88	407.08	410.65	-0.22	-0.2	0.01
7h	373.25	353.82	346.32	-0.08	-0.11	-0.03
23h	345.51	89.17	354.39	-1.95	0.04	1.99

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	472.88	373.25	345.51	-0.34	-0.45	-0.11
Ebov	407.08	353.82	89.17	-0.2	-2.19	-1.99
Marv	410.65	346.32	354.39	-0.25	-0.21	0.03

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	75.77	117.29	121.14	0.63	0.68	0.05
7h	100.85	96.27	102.62	-0.07	0.03	0.09
23h	81.62	58.74	101.59	-0.47	0.32	0.79

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	75.77	100.85	81.62	0.41	0.11	-0.31
Ebov	117.29	96.27	58.74	-0.28	-1.0	-0.71
Marv	121.14	102.62	101.59	-0.24	-0.25	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material