TIRAP

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TIRAP BACTS1, MAL,Mal, wyatt toll-interleukin 1 receptor (TIR) domain containing adaptor protein NM_148910 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

The gene is about 3 fold downregulated in the human cells 23h Ebola but not in the Marburg samples. Alas, the mapping of the bat cells genome did not work for this gene.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome49 38 36 36 36 11 39 35 26
Read_Max
batR. aegyptiacusTranscriptome 17 27 11 24 21 12 18 34 24
Read_Max
bat_genomeR. aegyptiacusGenome 41 30 29 31 18 16 26 40 35
DESeq
humanH. sapiensGenome 472.88 373.25 345.51 407.08 353.82 89.17 410.65 346.32 354.39
DESeq
batR. aegyptiacusTranscriptome 75.77 100.85 81.62 117.29 96.27 58.74 121.14 102.62 101.59
DESeq
bat_genomeR. aegyptiacusGenome 377.27 514.75 430.69 437.46 398.46 335.49 513.91 449.6 410.12

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 472.88 407.08 410.65 -0.22 -0.2 0.01
7h 373.25 353.82 346.32 -0.08 -0.11 -0.03
23h 345.51 89.17 354.39 -1.95 0.04 1.99

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 472.88 373.25 345.51 -0.34 -0.45 -0.11
Ebov 407.08 353.82 89.17 -0.2 -2.19 -1.99
Marv 410.65 346.32 354.39 -0.25 -0.21 0.03

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 75.77 117.29 121.14 0.63 0.68 0.05
7h 100.85 96.27 102.62 -0.07 0.03 0.09
23h 81.62 58.74 101.59 -0.47 0.32 0.79

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 75.77 100.85 81.62 0.41 0.11 -0.31
Ebov 117.29 96.27 58.74 -0.28 -1.0 -0.71
Marv 121.14 102.62 101.59 -0.24 -0.25 -0.01