IRAK4
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| IRAK4 | NY-REN-64 | interleukin-1 receptor-associated kinase 4 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Even though it is an important part of immune response signaling pathways the gene shows a low expression and there seems to be no difference between the different probes.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 34 | 62 | 43 | 38 | 62 | 31 | 43 | 53 | 48 |
Read_Max |  | R. aegyptiacus | Transcriptome | 82 | 71 | 53 | 97 | 96 | 67 | 63 | 101 | 116 |
Read_Max |  | R. aegyptiacus | Genome | 105 | 95 | 48 | 78 | 73 | 43 | 61 | 125 | 121 |
DESeq | | H. sapiens | Genome | 615.96 | 665.96 | 730.73 | 623.81 | 730.22 | 403.67 | 611.53 | 634.88 | 716.47 |
DESeq | | R. aegyptiacus | Transcriptome | 621.02 | 467.55 | 521.37 | 675.85 | 717.19 | 515.56 | 563.88 | 680.97 | 647.41 |
DESeq | | R. aegyptiacus | Genome | 1138.69 | 1170.97 | 846.88 | 994.4 | 1360.57 | 993.42 | 1196.5 | 1206.07 | 1080.51 |