ADAR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ADAR	ADAR1	adenosine deaminase, RNA-specific	NM_001111	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the enzyme responsible for RNA editing by site-specificdeamination of adenosines. This enzyme destabilizes double-stranded RNAthrough conversion of adenosine to inosine. Mutations in this gene have beenassociated with dyschromatosis symmetrica hereditaria. Alternative splicingresults in multiple transcript variants.

This gene shows no obvious irregularities.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1008	1041	956	982	1320	660	1241	1329	748
Read_Max	R. aegyptiacus	Transcriptome	164	118	123	113	97	114	104	122	150
Read_Max	R. aegyptiacus	Genome	190	121	111	113	83	67	89	148	155
DESeq	H. sapiens	Genome	30070.15	30192.3	28008.58	29097.54	29617.61	17850.17	29108.41	28705.67	24756.63
DESeq	R. aegyptiacus	Transcriptome	2156.8	2100.49	2229.08	1971.52	2092.62	2059.22	1934.36	2073.96	2284.86
DESeq	R. aegyptiacus	Genome	3013.88	2688.77	2860.85	3136.25	2965.57	2913.68	2828.2	2755.49	3091.71

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	30070.15	29097.54	29108.41	-0.05	-0.05	0.0
7h	30192.3	29617.61	28705.67	-0.03	-0.07	-0.05
23h	28008.58	17850.17	24756.63	-0.65	-0.18	0.47

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	30070.15	30192.3	28008.58	0.01	-0.1	-0.11
Ebov	29097.54	29617.61	17850.17	0.03	-0.7	-0.73
Marv	29108.41	28705.67	24756.63	-0.02	-0.23	-0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2156.8	1971.52	1934.36	-0.13	-0.16	-0.03
7h	2100.49	2092.62	2073.96	-0.01	-0.02	-0.01
23h	2229.08	2059.22	2284.86	-0.11	0.04	0.15

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2156.8	2100.49	2229.08	-0.04	0.05	0.09
Ebov	1971.52	2092.62	2059.22	0.09	0.06	-0.02
Marv	1934.36	2073.96	2284.86	0.1	0.24	0.14

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material