HERC6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HERC6 FLJ20637 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 pdf

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Description

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins.

The gene was only very slightly expressed in human cells and bat cells cells, no differences in expression were observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome4 4 3 5 3 5 4 3 7
Read_Max
batR. aegyptiacusTranscriptome 45 46 22 27 31 30 37 40 36
Read_Max
bat_genomeR. aegyptiacusGenome 55 30 21 51 29 19 33 58 53
DESeq
humanH. sapiensGenome 18.25 17.32 20.86 37.5 19.7 22.05 22.93 21.78 44.49
DESeq
batR. aegyptiacusTranscriptome 512.65 466.64 308.83 334.3 381.0 307.68 494.91 384.36 413.86
DESeq
bat_genomeR. aegyptiacusGenome 709.0 439.91 410.61 602.36 464.31 417.73 630.86 509.86 526.56

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 18.25 37.5 22.93 1.04 0.33 -0.71
7h 17.32 19.7 21.78 0.19 0.33 0.14
23h 20.86 22.05 44.49 0.08 1.09 1.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 18.25 17.32 20.86 -0.08 0.19 0.27
Ebov 37.5 19.7 22.05 -0.93 -0.77 0.16
Marv 22.93 21.78 44.49 -0.07 0.96 1.03

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 512.65 334.3 494.91 -0.62 -0.05 0.57
7h 466.64 381.0 384.36 -0.29 -0.28 0.01
23h 308.83 307.68 413.86 -0.01 0.42 0.43

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 512.65 466.64 308.83 -0.14 -0.73 -0.6
Ebov 334.3 381.0 307.68 0.19 -0.12 -0.31
Marv 494.91 384.36 413.86 -0.36 -0.26 0.11