TRIM25

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRIM25	Tripartite Motif Containing 25,ZNF14,EFP, RNF147	tripartite motif containing 25	NM_005082	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivationa domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

There might be a non-coding transcript located in the second, as we see about 300 reads mapping in this intron within the bat cells data and 10 in the human cells data, for each condition.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	74	67	87	80	103	26	86	126	63
Read_Max	R. aegyptiacus	Transcriptome	475	319	237	298	255	299	293	409	353
Read_Max	R. aegyptiacus	Genome	540	308	214	308	212	180	253	507	404
DESeq	H. sapiens	Genome	1360.81	1304.4	1588.53	1269.44	1161.08	298.4	1264.17	1480.6	1058.99
DESeq	R. aegyptiacus	Transcriptome	3009.54	2541.62	2441.63	2850.56	2755.15	2338.96	2774.23	2706.01	2308.48
DESeq	R. aegyptiacus	Genome	7071.06	6650.73	5414.87	6196.46	7077.4	6443.5	7113.79	6596.52	5752.75

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1360.81	1269.44	1264.17	-0.1	-0.11	-0.01
7h	1304.4	1161.08	1480.6	-0.17	0.18	0.35
23h	1588.53	298.4	1058.99	-2.41	-0.59	1.83

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1360.81	1304.4	1588.53	-0.06	0.22	0.28
Ebov	1269.44	1161.08	298.4	-0.13	-2.09	-1.96
Marv	1264.17	1480.6	1058.99	0.23	-0.26	-0.48

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3009.54	2850.56	2774.23	-0.08	-0.12	-0.04
7h	2541.62	2755.15	2706.01	0.12	0.09	-0.03
23h	2441.63	2338.96	2308.48	-0.06	-0.08	-0.02

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3009.54	2541.62	2441.63	-0.24	-0.3	-0.06
Ebov	2850.56	2755.15	2338.96	-0.05	-0.29	-0.24
Marv	2774.23	2706.01	2308.48	-0.04	-0.27	-0.23

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material