BAD

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BAD	BCL2-Associated Agonist Of Cell Death Bcl2 Antagonist Of Cell Death BCL2L BCL2-Binding Component Bcl-XL/Bcl-2-Associated Death Promoter BCL2-Binding Protein,BCL2L8, BBC2	BCL2-associated agonist of cell death	NM_032989	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. (provided by RefSeq, Jul 2008)

This is generally not well expressed in all conditions analyzed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	9	21	8	9	16	10	22	19	10
Read_Max	R. aegyptiacus	Transcriptome	42	66	35	37	34	41	43	65	63
Read_Max	R. aegyptiacus	Genome	66	55	47	82	37	30	37	79	98
DESeq	H. sapiens	Genome	96.39	99.93	72.48	81.99	83.11	76.01	79.95	96.12	66.24
DESeq	R. aegyptiacus	Transcriptome	136.26	177.09	191.56	119.12	128.03	131.88	143.39	139.8	200.43
DESeq	R. aegyptiacus	Genome	224.3	222.7	314.65	326.86	239.97	246.72	271.01	241.06	325.35

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	96.39	81.99	79.95	-0.23	-0.27	-0.04
7h	99.93	83.11	96.12	-0.27	-0.06	0.21
23h	72.48	76.01	66.24	0.07	-0.13	-0.2

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	96.39	99.93	72.48	0.05	-0.41	-0.46
Ebov	81.99	83.11	76.01	0.02	-0.11	-0.13
Marv	79.95	96.12	66.24	0.27	-0.27	-0.54

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	136.26	119.12	143.39	-0.19	0.07	0.27
7h	177.09	128.03	139.8	-0.47	-0.34	0.13
23h	191.56	131.88	200.43	-0.54	0.07	0.6

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	136.26	177.09	191.56	0.38	0.49	0.11
Ebov	119.12	128.03	131.88	0.1	0.15	0.04
Marv	143.39	139.8	200.43	-0.04	0.48	0.52

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

BAD